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  1. No Access

    Article

    CRAT links cholesterol metabolism to innate immune responses in the heart

    Chronic inflammation is associated with increased risk and poor prognosis of heart failure; however, the precise mechanism that provokes sustained inflammation in the failing heart remains elusive. Here we rep...

    Hua Mao, Aude Angelini, Shengyu Li, Guangyu Wang, Luge Li… in Nature Metabolism (2023)

  2. No Access

    Article

    Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats

    The effects of exercise on the heart and its resistance to disease are well-documented. Recent studies have identified that exercise-induced resistance to arrhythmia is due to the preservation of mitochondrial...

    Traci L. Parry, Joseph W. Starnes, Sara K. O’Neal, James R. Bain… in Metabolomics (2017)

  3. No Access

    Article

    Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates

    The ubiquitin–proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, a...

    Carrie E. Rubel, Jonathan C. Schisler, Eric D. Hamlett… in Cell Biochemistry and Biophysics (2013)

  4. No Access

    Protocol

    Reconstitution of CHIP E3 Ubiquitin Ligase Activity

    CHIP, the carboxyl-terminus of Hsp70 interacting protein, is both an E3 ubiquitin ligase and an Hsp70 co-chaperone and is implicated in the degradation of cytosolic quality control and numerous disease substra...

    Hong Yu Ren, Cam Patterson, Douglas M. Cyr, Meredith F. N. Rosser in Molecular Chaperones (2011)

  5. No Access

    Article

    Breast cancer quality control

    Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cel...

    Cam Patterson, Sarah Ronnebaum in Nature Cell Biology (2009)

  6. No Access

    Article

    Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

    Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via a mechanism distinct from other Hsp70 nucleotide-...

    Zhen Xu, Richard C Page, Michelle M Gomes… in Nature Structural & Molecular Biology (2008)

  7. No Access

    Chapter

    Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP

    Following exposure to environmental insults, the cells in most tissues dramatically increase the production of a group of proteins that are collectively known as “heat shock” or stress proteins (Parsell and Lindq...

    Shu-Bing Qian, Cam Patterson in Cell Stress Proteins (2007)

  8. No Access

    Protocol

    Cystic Fibrosis Transmembrane Conductance Regulator as a Model Substrate to Study Endoplasmic Reticulum Protein Quality Control in Mammalian Cells

    Components of the ubiquitin-proteasome system function on the surface of the endoplasmic reticulum (ER) to select misfolded proteins for degradation. Herein we describe methods that allow for the study of the ...

    J. Michael Younger, Chun-Yang Fan, Liling Chen… in Ubiquitin-Proteasome Protocols (2005)

  9. No Access

    Article

    The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

    To maintain quality control in cells, mechanisms distinguish among improperly folded peptides, mature and functional proteins, and proteins to be targeted for degradation. The molecular chaperones, including h...

    Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu… in Nature Cell Biology (2001)

  10. No Access

    Article

    The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

    The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient1,2,3,4. Most nascent CFTR is retained in th...

    Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger… in Nature Cell Biology (2001)

  11. No Access

    Article

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB (NF-κB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqui Han… in Molecular and Cellular Biochemistry (2000)

  12. No Access

    Chapter

    Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-кB (NF-кB) transcription factor

    The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a major source of circulating pla...

    Allan R. Brasier, M. Jamaluddin, Youqi Han… in Control of Gene Expression by Catecholamin… (2000)

  13. No Access

    Article

    Genomic structure of the human KDR/flk-1 gene

    Li-Yan Yin, Yaxu Wu, Carol A. Ballinger, Cam Patterson in Mammalian Genome (1998)