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Article
Publisher Correction: OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues
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Article
OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues
Non-destructive fluorophore diffusion across cell membranes to provide an unbiased fluorescence intensity readout is critical for quantitative imaging applications in live cells and tissues. Commercially avail...
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Article
Open AccessTurning antibodies off and on again using a covalently tethered blocking peptide
In their natural form, antibodies are always in an “on-state” and are capable of binding to their targets. This leads to undesirable interactions in a wide range of therapeutic, analytical, and synthetic appli...
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Protocol
A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Develo** Mouse Inner Ear
There is keen interest to define gene therapies aimed at restoration of auditory and vestibular function in the diseased or damaged mammalian inner ear. A persistent limitation of regenerative medical strategi...
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Article
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via a mechanism distinct from other Hsp70 nucleotide-...
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Article
IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential
IgA antibodies play an important role in humoral immunity. IgA is the predominant antibody in mucosal secretions and the second most prevalent in the serum. It occupies a unique position among human antibodies...
