Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.
This is a preview of subscription content, log in via an institution to check access.
References
Kajiro M. et al. The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nature Cell Biol. 11, 312–319 (2009).
Tateishi, Y. et al. Ligand-dependent switching of ubiquitin–proteasome pathways for estrogen receptor. EMBO J. 23, 4813–4823 (2004).
Wu, R. C., Feng, Q., Lonard, D. M. & O'Malley, B. W. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell 129, 1125–1140 (2007).
Koepp, D. M. et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294, 173–177 (2001).
Connell, P. et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nature Cell Biol. 3, 93–96 (2001).
McDonough, H. & Patterson, C. CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones 8, 303–308 (2003).
Dai, Q. et al. CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 22, 5446–5458 (2003).
Dickey, C. A. et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J. Neurosci. 26, 6985–6996 (2006).
Sanbe, A. et al. Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc. Natl Acad. Sci. USA 102, 13592–13597 (2005).
Neckers, L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. 8, S55–S61 (2002).
**n, H. et al. CHIP controls the sensitivity of transforming growth factor-β signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation. J. Biol. Chem. 280, 20842–20850 (2005).
Dai, C., Whitesell, L., Rogers, A. B. & Lindquist, S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130, 1005–1018 (2007).
Min, J. N. et al. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol. Cell. Biol. 28, 4018–4025 (2008).
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Patterson, C., Ronnebaum, S. Breast cancer quality control. Nat Cell Biol 11, 239–241 (2009). https://doi.org/10.1038/ncb0309-239
Issue Date:
DOI: https://doi.org/10.1038/ncb0309-239
- Springer Nature Limited
This article is cited by
-
E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells
Clinical and Experimental Medicine (2020)
-
Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer
Tumor Biology (2012)