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Open AccessNeuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased mortality risk for people with Alzheimer’s disease (AD) and/or ...
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p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia
The accumulation of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer’s disease (AD) pathology. Microglial activation-mediated neuroinflammation has been implicated in the pathogenesis of AD an...
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Article
Open AccessNeuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
In order for Alzheimer’s disease (AD) to manifest, cells must communicate “pathogenic material” such as proteins, signaling molecules, or genetic material to ensue disease propagation. Small extracellular vesi...
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Protocol
Identification and Characterization of Protein Posttranslational Modifications by Differential Fluorescent Labeling
Analysis of posttranslational modifications (PTMs) of proteins is of major interest in current biomedical research due to the multiple roles played by PTMs in protein regulation and function. In general this i...
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Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates
The ubiquitin–proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, a...
