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Article
Open AccessPhage-layer interferometry: a companion diagnostic for phage therapy and a bacterial testing platform
The continuing and rapid emergence of antibiotic resistance (AMR) calls for innovations in antimicrobial therapies. A promising, ‘re-emerging’ approach is the application of bacteriophage viruses to selectivel...
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Article
Open AccessA single-dose, open-label, randomized, scintigraphic study to investigate the gastrointestinal behavior of 2 triple-combination cold products (acetaminophen, phenylephrine, and dextromethorphan) in healthy male volunteers
Common cold symptoms may be mitigated by products in caplet, nasal spray, and oral solution formulations, although variations exist in the bioavailability of the active ingredients contained within these produ...
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Article
Open AccessCHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, ...
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Article
An integrated biophysical approach to discovering mechanisms of NDM-1 inhibition for several thiol-containing drugs
Due to the rapid proliferation of antibiotic-resistant pathogenic bacteria, known as carbapenem-resistant enterobacteriaceae, the efficacy of β-lactam antibiotics is threatened. β-lactam antibiotics constitute...
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Article
1H, 13C, and 15N backbone resonance assignments for KPC-2, a class A serine-β-lactamase
The ever-increasing occurrence of antibiotic resistance presents a major threat to public health. Specifically, resistance conferred by β-lactamases places the efficacy of currently available antibiotics at ri...
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Article
Open AccessAbstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
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Open Access1H, 15N and 13C resonance assignments for free and IEEVD peptide-bound forms of the tetratricopeptide repeat domain from the human E3 ubiquitin ligase CHIP
The ubiquitin ligase CHIP catalyzes covalent attachment of ubiquitin to unfolded proteins chaperoned by the heat shock proteins Hsp70/Hsc70 and Hsp90. CHIP interacts with Hsp70/Hsc70 and Hsp90 by binding of a ...
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Article
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
The adaptor Act1 links the interleukin 17 receptor to downstream signaling pathways. Li and colleagues show that phosphorylation of Act1 by the kinase IKKi is necessary for recruitment of the adaptors TRAF2 an...
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Article
Intranasal versus Oral Administration of Lisdexamfetamine Dimesylate
Background and Objective: Data on pharmacokinetic parameters of the prodrug stimulant lisdexamfetamine dimesylate via alternate routes of administration are limited. The pharmacokinetics of d-amp...
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Article
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via a mechanism distinct from other Hsp70 nucleotide-...
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Article
Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins
The preparation of high quality samples is a critical challenge for the structural characterization of helical integral membrane proteins. Solving the structures of this diverse class of proteins by solution n...
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Article
Evaluation of the in Vivo Disintegration of Solid Dosage Forms of a Bile Acid Sequestrant in Dogs Using γ-Scintigraphy and Correlation to in Vitro Disintegration
Purpose. To evaluate the in vivo disintegration behavior of tablets and capsules of a bile acid sequestrant, DMP 504, in beagle dogs and to assess the significance of the in vitro disintegration of the dosage fo...
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Article
A comparison of perceptions of self among university students in Ireland and the U.S.: Implications for counselling
The study compared 50 Irish and 50 American graduateand undergraduate psychology and counselling studentson the ways they rated My Real Self and My Ideal Selfon a Semantic Differential using Osgood et al.'s (1...
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In Vivo Evaluation of the Absorption and Gastrointestinal Transit of Avitriptan in Fed and Fasted Subjects Using Gamma Scintigraphy
The study was conducted to assess the bioavailability of avitriptan after a standard high fat meal, in relation to gastrointestinal transit. Six healthy male subjects were enrolled in a four-period study with .....
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Article
A comparison of Thai and American counselling students perceptions of counselling
The expectancies that people of different cultures bring to counselling affect the outcomes of counselling. It was the purpose of this study to examine the ways that counselling students in two different count...
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Marathon Group Therapy with Illicit Drug Users
Marathon group therapy offers the skilled therapist a means of creating a therapeutic environment in which illicit drug users can work to resolve their personal problems and to improve the quality of their int...
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Article
The perceptions of spinal cord injured persons toward sex
An instrument called the Marital Adjustment Checklist for the Disabled was individually administered to 38 male and female back-injured persons. The responses of the subjects to the sexual problems section of ...
