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44 Result(s)
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C. Muller
Biomedicine
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Article
Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?
Genome-wide association studies have identified and repeatedly confirmed the association of rs3197999 in MST1 with inflammatory bowel disease (IBD). However, the underlying pathophysiology remains unclear. rs3197...
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Article
−295 T-to-C promoter region IL-16 gene polymorphism is associated with Whipple’s disease
Whipple’s disease (WD) is a rare systemic condition caused, in genetically predisposed subjects, by Tropheryma whipplei, a common bacterium widespread in the environment. The relevance of genetic predisposition i...
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Article
Decreased global DNA methylation in the white blood cells of high fat diet fed vervet monkeys (Chlorocebus aethiops)
Epigenetic mechanisms are associated with the development of many chronic diseases and due to their reversible nature offer a unique window of opportunity to reverse the disease phenotype. This study investiga...
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Article
Cytokine genetic profile in Whipple’s disease
Whipple’s disease (WD) is a very rare chronic systemic condition characterised by a Th2/T regulatory (Treg) dysregulated immune response versus Tropheryma whipplei, a bacterium widely diffuse in the environment. ...
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Article
Evidence for repetitive load in the trapezius muscle during a tap** task
Many studies describe the trapezius muscle activation pattern during repetitive key-tap** focusing on continuous activation. The objectives of this study were to determine whether the upper trapezius is phas...
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Article
Factors influencing the pharmacokinetics of prophylactic posaconazole oral suspension in patients with acute myeloid leukemia or myelodysplastic syndrome
To estimate the pharmacokinetic (PK) properties of posaconazole in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing chemotherapy in a clinical setting.
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Article
Population fragmentation leads to isolation by distance but not genetic impoverishment in the philopatric Lesser Kestrel: a comparison with the widespread and sympatric Eurasian Kestrel
Population fragmentation is a widespread phenomenon usually associated with human activity. As a result of habitat transformation, the philopatric and steppe-specialist Lesser Kestrel Falco naumanni underwent a s...
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Article
Open AccessAssessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis – a pilot study
Lymphomatous meningitis (LM) represents a severe complication of malignant lymphomas. While clinical suspicion is raised by symptoms ranging from mild disturbances of sensation to severe pain or impaired consc...
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Article
Open AccessEnhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted c...
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Article
Open AccessNitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells
Cutaneous melanoma is one of the highly malignant human tumours, due to its tendency to generate early metastases and its resistance to classical chemotherapy. We recently demonstrated that pamidronate, a nitr...
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Article
Chemical defence in a sawfly: genetic components of variation in relevant life-history traits
Larvae of several tenthredinid sawfly species readily release droplets of haemolymph through their integument when attacked by predators. This defence mechanism via ‘bleeding’ is characterised by a low integum...
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Article
Open AccessDecreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation
Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to i...
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Article
A DNA probe for the detection of Dicrocoelium dendriticum in ants of Formica spp. and Lasius spp.
Repetitive DNA sequences present in the genome of Dicrocoelium dendriticum were identified by hybridization of genomic DNA that had been digested with different restriction enzymes with 32P-labeled genomic D. de...
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Article
Psychotropic drug intake in residents newly admitted to nursing homes
While several surveys have shown that psychotropic drugs are frequently used by nursing home residents, no studies have been performed to investigate whether the rates of drug use increase during the stay in ...
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Article
An immunohistochemical analysis of the ontogeny, distribution and coexistence of 12 regulatory peptides and serotonin in endocrine cells and nerve fibers of the digestive tract of the turbot, Scophthalmus maximus (Teleostei)
The ontogeny of endocrine cells and nerve fibers containing immunoreactivities for 12 regulatory peptides and serotonin was studied in the digestive tract of a flatfish, the turbot (Scophthalmus maximus), using ...
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Article
Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression
Active T cell suicide (apoptosis) is supposed to be involved in the CD4+ T cell depletion in the course of HIV infection. We investigated the expression of the apoptosis-related antigen Fas on CD4+ T cells from 2...
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Chapter
Clinical Markers of Alcohol Abuse
The term “marker”, which was originally introduced in molecular genetics and is now also established in research on psychoses and alcoholism, has the same meaning as “indicator”, at least as long as no true ge...
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Article
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
A pharmacokinetic study with 30 mg propiverine p.o. was performed in healthy volunteers (10 males, 6 females, age 36–56 years, body weight 55–100 kg, body height 162–184 cm, Broca index 0.96–1.19). 8 of them w...
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Book
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Article
Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers
The distribution of Gp 170, a multidrug resistance (MDR) associated glycoprotein, also called P-glycoprotein (P-gp), was examined by immunohistochemistry, using C219 and MRK16 monoclonal antibodies. Sixty-five...
