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  1. No Access

    Article

    Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-κB but is related to downregulation of initiator caspases and DR4

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention as a novel anticancer agent. However, its efficiency may be diminished by occurring resistance in cancer cel...

    B M Kurbanov, L F Fecker, C C Geilen, W Sterry, J Eberle in Oncogene (2007)

  2. No Access

    Article

    A novel Bcl-x splice product, Bcl-xAK, triggers apoptosis in human melanoma cells without BH3 domain

    Pro- and antiapoptotic proteins of the large Bcl-2 family are critical regulators of apoptosis via the mitochondrial pathway. Whereas antiapoptotic proteins of the family share all four Bcl-2 homology domains ...

    A M Hossini, C C Geilen, L F Fecker, P T Daniel, J Eberle in Oncogene (2006)

  3. Article

    Open Access

    Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells

    Cutaneous melanoma is one of the highly malignant human tumours, due to its tendency to generate early metastases and its resistance to classical chemotherapy. We recently demonstrated that pamidronate, a nitr...

    A-M Forsea, C Müller, C Riebeling, C E Orfanos, C C Geilen in British Journal of Cancer (2004)

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  4. Article

    Open Access

    The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro

    Pamidronate belongs to the class of nitrogen-containing bisphosphonates that are potent inhibitors of bone resorption frequently used for the treatment of osteoporosis and cancer-induced osteolysis. The inhibi...

    C Riebeling, A-M Forsea, M Raisova, C E Orfanos, C C Geilen in British Journal of Cancer (2002)

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  5. Article

    Open Access

    Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1

    Control of translation initiation was recognised as a critical checkpoint for cell proliferation and tumorigenesis. In human melanoma cells, we have previously reported consistent overexpression of translation...

    J Eberle, L F Fecker, J-U Bittner, C E Orfanos, C C Geilen in British Journal of Cancer (2002)

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  6. No Access

    Book

    Therapie der Hautkrankheiten

    einschließlich Allergologie, Andrologie, Phlebologie, Proktologie, Trichologie, pädiatrische Dermatologie, tropische Dermatosen, Venerologie und HIV-Infektion sowie dermatologische Notfälle

    U. Blume-Peytavi, C. C. Geilen, S. Goerdt… (2002)

  7. No Access

    Article

    Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor α and 1α,25-dihydroxyvitamin D3

    V. Müller-Wieprecht, C. Riebeling, A. Stooss… in Archives of Dermatological Research (2000)

  8. No Access

    Chapter

    Therapeutic uses of retinoids in skin diseases

    Since retinol became available in the mid 1940s, at least 2500 different retinoids, structurally related to retinol, were synthesized. Dermatologists have played a leading role in develo** this new class of ...

    C. C. Geilen, B. Almond-Roesler… in Vitamin A and Retinoids: An Update of Biol… (2000)

  9. No Access

    Article

    The phospholipid analogue hexadecylphosphocholine (HePC) inhibits proliferation of keloid fibroblasts in vitro and modulates their fibronectin and integrin synthesis

    Hexadecylphosphocholine (HePC), a topically effective compound, exerts a strong antiproliferative effect on neoplastic cells. In the present study we investigated (1) the antiproliferative effect...

    U. Blume-Peytavi, C. C. Geilen, C. Sommer… in Archives of Dermatological Research (1997)

  10. No Access

    Chapter and Conference Paper

    Hexadecylphosphocholine as an Useful Tool for Investigating Phosphatidylcholine Biosynthesis and Sorting

    Phosphatidylcholine is the most abundant phospholipid in mammalian tissues. The main route of its biosynthesis is the CDP-choline pathway with CTP : choline phosphate cytidylyltransferase (CT) (EC 2.7.7.15) as...

    C. C. Geilen, Th. Wieder, W. Reutter in Molecular Mechanisms of Membrane Traffic (1993)

  11. No Access

    Chapter and Conference Paper

    A 38 kDa Protein Resident to CIS Golgi Apparatus Cisternae of Rat Liver is Recognized by an Antibody Directed Against α Subunits of Trimeric G-Proteins

    Using a completely cell-free system from rat liver, we have demonstrated the formation of 50–70 nm ATP-dependent transfer vesicles and the transfer of both lipids and proteins to Golgi apparatus immobilized on...

    A. O. Brightman, M. Paulik, J. B. Lawrence… in Molecular Mechanisms of Membrane Traffic (1993)

  12. No Access

    Article

    101 Incorporation of different radiolabeled N-acyl-2-amino-2-deoxy-d-hexoses into gangliosides

    H. Kayser, C. C. Geilen, C. Paul, R. Zeitler… in Fresenius' Journal of Analytical Chemistry (1992)

  13. No Access

    Article

    102 Modulation of glycoconjugate biosynthesis by the incorporation of the galactose analogue 2-deoxy-d-galactose

    C. C. Geilen, C. Kannicht, Y. -H. Hwang… in Fresenius' Journal of Analytical Chemistry (1992)