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Article
Open AccessEnhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted c...
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Article
Transgene expression is increased by photochemically mediated transduction of polycation-complexed adenoviruses
Poor efficiency of adenoviral gene transfer to target cells is a major limitation to adenoviral gene therapy. Inefficient gene transfer occurs in the absence of coxsackie- and adenovirus receptor (CAR) on the ...
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Article
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas
We have examined apoptosis and proliferation in lymph node cell suspensions from patients with B-cell non-Hodgkin's lymphoma using flow cytometry. A method was developed which allowed estimation of the fractio...
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Article
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland
Reduced expression of nm23/NDP kinase and increased expression of cathepsin D seem to be correlated with the high metastatic potential in a variety of malignancies. The expression of nm23/NDP kinase and that o...
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Article
Detection of necrosis in human tumour xenografts by proton magnetic resonance imaging
Tumours with necrotic regions have an inadequate blood supply and are expected to differ from well-vascularised tumours in response to treatment. The purpose of the present work was to investigate whether prot...
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Article
Pre- and post-treatment sexual life in testicular cancer patients: a descriptive investigation
Aspects of sexuality were assessed by questionnaires in 76 testicular cancer patients after orchiectomy before further treatment and, respectively, 6, 12 and 36 months after therapy. Before treatment 11% of th...
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Article
Long-term somatic side-effects and morbidity in testicular cancer patients
In order to evaluate long-term somatic morbidity after treatment for testicular cancer 149 patients with NED greater than or equal to 3 years answered a questionnaire. The patients had been treated with surger...
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Is Determination of Prostatic Acid Phosphatase in Bone Marrow by Radioimmunoassay (BM-PAP) Useful in Patients with Prostatic Cancer?
Prostatic acid phosphatase (PAP) determined in serum and bone marrow, is claimed to be a useful tumour marker in prostatic carcinoma (1,2,3,4). The clinical significance of bone marrow PAP (BM-PAP) has, howeve...
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Article
Cell proliferation kinetics in two human tumors grown in athymic nude mice
The technique of labelled mitoses was used to investigate the cell proliferation kinetics in two human neoplasms, one a malignant melanoma and one a fibrosarcoma, transplanted to and grown serially in the athy...