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  1. No Access

    Article

    Mechanisms of resistance to combinations of vincristine, etoposide and doxorubicin in Chinese hamster ovary cells

    We have isolated from Chinese hamster ovary cells, 30 sublines resistant to vincristine, doxorubicin or etoposide and 43 sublines evading treatment with a pair of these drugs. Isolated in one step and under lo...

    S Souès, F Laval, J-Y Charcosset in British Journal of Cancer (1995)

  2. No Access

    Article

    Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells

    As an approach to the rational design of combination chemotherapy involving the anti-cancer DNA topoisomerase II poison etoposide (VP-16), we have studied the dynamic changes occurring in small-cell lung cance...

    PJ Smith, S Souès, T Gottlieb, SJ Falk, JV Watson, RJ Osborne… in British Journal of Cancer (1994)

  3. No Access

    Article

    Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers

    The distribution of Gp 170, a multidrug resistance (MDR) associated glycoprotein, also called P-glycoprotein (P-gp), was examined by immunohistochemistry, using C219 and MRK16 monoclonal antibodies. Sixty-five...

    D Schlaifer, G Laurent, S Chittal, T Tsuruo, S Soues, C Muller… in British Journal of Cancer (1990)