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  1. No Access

    Article

    Sumoylation of ING2 regulates the transcription mediated by Sin3A

    ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence. Although the functions of ING2 within the chromatin remodeling complex Sin3A/histone ...

    D Ythier, D Larrieu, R Binet, O Binda, C Brambilla, S Gazzeri, R Pedeux in Oncogene (2010)

  2. No Access

    Article

    Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

    Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly...

    C Caron, C Lestrat, S Marsal, E Escoffier, S Curtet, V Virolle, P Barbry… in Oncogene (2010)

  3. No Access

    Article

    The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

    The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular en...

    G Merdzhanova, S Gout, M Keramidas, V Edmond, J-L Coll, C Brambilla… in Oncogene (2010)

  4. No Access

    Article

    Robot-assisted laparoscopic gastrectomy with D2 dissection for adenocarcinoma: initial experience with 17 patients

    Robot-assisted gastrectomy has been practised so far in very few centres in the world. The aims of this study were to assess the feasibility of robot-assisted gastrectomy for adenocarcinoma with D2 lymph nodal...

    R. Pugliese, D. Maggioni, F. Sansonna, G. C. Ferrari… in Journal of Robotic Surgery (2008)

  5. No Access

    Article

    Pulmonary nodule detection on MDCT images: evaluation of diagnostic performance using thin axial images, maximum intensity projections, and computer-assisted detection

    This study aimed at evaluating the diagnostic benefits of maximum intensity projections (MIP) and a commercially available computed-assisted detection system (CAD) for the detection of pulmonary nodules on MDC...

    A. Jankowski, T. Martinelli, J. F. Timsit, C. Brambilla, F. Thony… in European Radiology (2007)

  6. No Access

    Article

    E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors

    The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated th...

    C Salon, G Merdzhanova, C Brambilla, E Brambilla, S Gazzeri, B Eymin in Oncogene (2007)

  7. Article

    Open Access

    Functional serotonin 5–HTTLPR polymorphism is a risk factor for migraine with aura

    In the present work, we report that the functional serotonin transporter gene promoter (5–HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5–HTTLPR genotypes was significantly dif...

    B. Borroni, C. Brambilla, P. Liberini, R. Rao… in The Journal of Headache and Pain (2005)

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  8. No Access

    Chapter

    Génomique et protéomique dans la détection précoce du cancer

    Les résultats obtenus à ce jour dans le traitement du cancer du poumon restent décevants. La faible survie s’explique par une prise en charge à un stade souvent localement avancé ou métastatique, qui ne relève...

    S. Diab, D. Moro-Sibilot, C. Brambilla in Le dépistage du cancer bronchique : de l’e… (2005)

  9. No Access

    Article

    Phase I/II study of gemcitabine in association with vinorelbine for metastatic breast cancer

    Background. Gemcitabine (G) and vinorelbine (V) have favorable safety profile and antitumor activity in metastatic breast cancer. To exploit their different mechanism of action and lack of overlap** toxicity, ...

    G. Mariani, P. Tagliabue, P. Zucchinelli… in Breast Cancer Research and Treatment (2001)

  10. No Access

    Article

    Endovascular treatment of superior vena cava obstruction in patients with malignancies

    The aim of this study was to report our experience on the management of superior vena cava obstruction (SVCO) secondary to malignant disease, using endovascular procedures. Twenty-six patients with SVCO due t...

    F. Thony, D. Moro, P. Witmeyer, S. Angiolini, C. Brambilla… in European Radiology (1999)

  11. No Access

    Article

    A retrospective evaluation of HLA-A, B and -DRB1 matching in liver transplantation

    Studies on the influence of histocompatibility in liver transplantation have not produced clear-cut results. We retrospectively studied the influence of HLA-A, B and -DRB1 matching on the survival of 517 live...

    F. Poli, M. Scalamogna, A. Aniasi, C. Brambilla, M. Cardillo… in Transplant International (1998)

  12. No Access

    Article

    Central airway stenoses: preliminary results of spiral-CT-generated virtual bronchoscopy simulations in 29 patients

    The purpose of this study was to determine the feasibility of using virtual bronchoscopy simulations to depict stenoses of the tracheobronchial tree. Virtual bronchoscopy simulations, based on ray casting, we...

    G. R. Ferretti, J. Knoplioch, I. Bricault, C. Brambilla, M. Coulomb in European Radiology (1997)

  13. No Access

    Chapter and Conference Paper

    Primary Chemotherapy for Resectable Breast Cancer

    Primary (neoadjuvant, preoperative) chemotherapy for surgically curative breast cancer is a novel treatment approach. The sequentially combined strategy derives from prior experience achieved with locally adva...

    G. Bonadonna, U. Veronesi, C. Brambilla, L. Ferrari… in Adjuvant Therapy of Breast Cancer IV (1993)

  14. No Access

    Chapter and Conference Paper

    Changes in Left Ventricular Ejection Fraction During Arterial REM Sleep Desaturation and Exercise in Chronic Obstructive Pulmonary Disease and Sleep Apnea Syndrome

    Exercise and rapid eye movement (REM) sleep are two important states during which oxyhemoglobin desaturation may occur in chronic obstructive pulmonary disease (COPD) [1, 2]. Sleep apnea also leads to oxygen d...

    C. M. Pison, J. M. Gaio, D. Fagret, P. Romand, P. A. Levy… in Sleep and Health Risk (1991)

  15. No Access

    Chapter and Conference Paper

    Salvage Treatments in Relapsing Resectable Breast Cancer

    There is convincing evidence that the natural history of resectable breast cancer can be perturbed by adjuvant medical intervention. In fact, a highly significant reduction in the recurrence rate has been docu...

    P. Valagussa, C. Brambilla, M. Zambetti… in Adjuvant Therapy of Primary Breast Cancer (1989)

  16. No Access

    Chapter and Conference Paper

    The Milan Experience with Adjuvant Chemotherapy in Premenopausal Breast Cancer

    In spite of the many scientific and clinical debates which have involved adjuvant chemotherapy for high-risk resectable breast cancer, there is general agreement that polydrug regimens, in particular, CMF (cyc...

    G. Bonadonna, P. Valagussa, M. Zambetti… in Adjuvant Therapy of Primary Breast Cancer (1989)

  17. No Access

    Chapter

    Chemotherapy of Advanced Disease

    During the past 15 years, the potential of cytotoxic agents to palliate, or even cure in a few instances, metastatic breast cancer has undoubtedly reached a plateau. Despite innumerable reports dealing with pr...

    P. Valagussa, C. Brambilla, G. Bonadonna in Breast Cancer (1989)

  18. No Access

    Chapter

    Validation (Test Set) of a Method for Detecting Associated Heart Conditions in LBBB by Means of BSM

    We recently reported (1) a procedure for detecting associated heart condition(s) in left bundle branch block (LBBB), based on a multivariate analysis (Fisher’s discriminant analysis (2) of 10 voltage related v...

    E. Musso, D. Stilli, C. Brambilla… in Electrocardiographic Body Surface Map** (1986)

  19. No Access

    Chapter

    Adjuvant Programs for Postmenopausal Women with Node-Positive Breast Cancer:Preliminary Analysis of 5-Year Results

    The results of the first CMF program (cyclophosphamide, methotrexate, and fluorouracil given for 12 monthly cycles) indicated only a slight benefit for the subgroup of postmenopausal patients with node-positiv...

    A. Rossi, C. Brambilla, P. Valagussa… in Adjuvant Chemotherapy of Breast Cancer (1984)

  20. No Access

    Chapter

    Relationship Between Estrogen Receptors and CMF Adjuvant Chemotherapy

    The presence of estrogen receptors (ER) has been found to have prognostic significance in patients with resectable breast cancer, regardless of whether axillary nodes are positive or negative [12, 14]. Since a...

    G. Bonadonna, G. Di Fronzo, G. Tancini… in Clinical Interest of Steroid Hormone Recep… (1984)

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