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Article
Adjuvant chemotherapy for operable breast cancer: old vs new schema
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Article
Double-Peaked Time Distribution of Mortality for Breast Cancer Patients Undergoing Mastectomy
Purpose. To gather information on the natural history of breast cancer from the time-distribution of deaths of patients undergoing mastectomy alone.
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Article
Phase I/II study of gemcitabine in association with vinorelbine for metastatic breast cancer
Background. Gemcitabine (G) and vinorelbine (V) have favorable safety profile and antitumor activity in metastatic breast cancer. To exploit their different mechanism of action and lack of overlap** toxicity, ...
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Article
Open AccessDoes surgery modify growth kinetics of breast cancer micrometastases?
Surgery should be considered as a major perturbing factor for metastasis development in laboratory animals. The different time distribution of mortality for 1173 patients undergoing mastectomy in comparison wi...
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Article
Elevated pretreatment serum levels of Il-10 are associated with a poor prognosis in hodgkin's disease, the Milan Cancer Institute Experience
Alterated cytokine secretion may play a role in determining Hodgkin's disease-related immunosuppression. The aim of this study was to analyze the clinical significance of interleukin-10(IL-10) serum levels in ...
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Article
Soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease: outcome and clinical implications
The aim of this study was to assess the prognostic role of soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease (HD) both in the achievement of complete remission (CR) and in predicting disease relaps...
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Chapter and Conference Paper
Putting Taxanes to Work in Operable Breast Cancer: A Search for Selective Indications from Empirical Studies
Based on their unique and novel mechanism of action, the taxanes paclitaxel (PCT) and docetaxel (DCT) have been extensively studied in solid tumors. The two drugs found in the field of breast cancer an arena o...
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Article
Five-day infusion fluorouracil plus vinorelbine i.v. in metastatic pretreated breast cancer patients
The aim of the present study was to evaluate the clinical activity and side effects of a combination chemotherapy consisting of a five-day continuous infusion of fluorouracil and i.v. vinorelbine in metastatic...
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Chapter and Conference Paper
Future Developments in Adjuvant Systemic Therapy for High-Risk Breast Cancer
In an article written by B. Fisher (1984), the following statement can be found: “Competing forces have continuously played a role in determining the management of breast cancer.” This statement should remind ...
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Chapter and Conference Paper
Reproductive Potential After Adjuvant Chemotherapy for Breast Cancer
The 10-year update of the world-wide overview of breast cancer treatment (Early Breast Cancer Trialists’ Collaborative Group 1992) has confirmed that adjuvant systemic therapy can alter the course of breast ca...
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Article
Serum LP(A) levels in randomized healthy men from different European countries
Serum lipoprotein(a) [Lp(a) ], blood lipids, serum insulin and anthropometric parameters were determined in randomized samples of 38-year-old men living in six European cities: Ede (The Netherlands), Deinze (Belg...
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Chapter and Conference Paper
Long-Term Sequelae from Adjuvant Chemotherapy
It has been estimated that 5000000 Americans living in 1987 have had cancer at some time during their lives, and that 3000000 have survived 5 years or longer, largely because of improvement in early detection ...
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Chapter and Conference Paper
Primary Chemotherapy for Resectable Breast Cancer
Primary (neoadjuvant, preoperative) chemotherapy for surgically curative breast cancer is a novel treatment approach. The sequentially combined strategy derives from prior experience achieved with locally adva...
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Chapter and Conference Paper
What Did We Learn from the Results of the International Overview about the Effects of Endocrine Therapy?
The simple answer to the question posed in the title to this chapter is that we have learned, as already expected, that adjuvant endocrine therapy is effective. Indeed, both ovarian ablation and tamoxifen have...
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Chapter and Conference Paper
Primary chemotherapy and surgery in advanced oral cavity squamous cell carcinomas : retrospective analysis
Chemotherapy is usually employed for head and neck squamous cell carcinomas only in the advanced disease setting. The best regimen has not yet been defined, due to the lack of controlled trials and to differen...
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Chapter
Adjuvant Chemotherapy Programs in Node-Negative Breast Cancer
Traditionally, women with node-negative breast cancer have been regarded as having a relatively favorable prognosis following locoregional therapy (surgery and/or radiotherapy) although for more than 10 years ...
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Chapter and Conference Paper
Combined approach to malignant small round blue cell neoplasms in the adult
Small round blue cell neoplasms are common malignancies in the childhood but are rare in the adults. They include Ewing’s sarcoma, peripheral neuroepithelioma, and rhabdomyosarcoma. Ewing’s sarcoma
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Chapter and Conference Paper
Recombinant Human GM-CSF for Large-Scale Collection of Circulating Hematopoietic Progenitors in Cancer Patients Treated with High-Dose Cyclophosphamide
Experimental evidences indicate that human hematopoietic stem cells belong to a subset of undifferentiated bone marrow cells expressing a surface membrane glycoprotein of 110–120 kDa designated CD34 antigen [1...
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Chapter and Conference Paper
Hodgkin’s Disease: The Milan Cancer Institute Experience with MOPP and ABVD
This paper briefly reports the Milan Cancer Institute experience on Hodgkin’s disease treated with an Adriamycin- and bleomycin-based combination (ABVD: Adriamycin, bleomycin, vinblastine, and dacarbazine). Fo...
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Chapter and Conference Paper
Adjuvant Chemotherapy for Node-Negative Breast Cancer Patients
Recent results have confirmed that adjuvant systemic therapies increase the relapse-free survival (RFS) and overall survival (OS) of patients with resectable breast cancer (Bonadonna and Valagussa 1988; Early ...
