26 Result(s)
within
C. Bergeron
English
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Article
Open AccessLow expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells by modulating metabolism and death pathways
Rhabdomyosarcoma (RMS) is the most frequent form of pediatric soft-tissue sarcoma. It is divided into two main subtypes: ERMS (embryonal) and ARMS (alveolar). Current treatments are based on chemotherapy, surg...
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Article
Should busulfan therapeutic range be narrowed in pediatrics? Experience from a large cohort of hematopoietic stem cell transplant children
Busulfan, the corner stone of hematopoietic stem cell transplantation regimens, has a narrow therapeutic window. Therapeutic drug monitoring (TDM)-guided dosing to reach the conventional area under the concent...
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Article
Open AccessTreatment and outcome of patients with relapsed clear cell sarcoma of the kidney: a combined SIOP and AIEOP study
Clear cell sarcoma of the kidney (CCSK) is an uncommon paediatric renal tumour. Relapses occur in about 15% of the patients. Since detailed clinical information on relapsed CCSK is scarce, the current study ai...
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Article
Open AccessA novel method for predicting ligand regioselectivity to metabolism by the CYP3A4 enzyme
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Article
Open AccessTemporal Scalability through Adaptive -Band Filter Banks for Robust H.264/MPEG-4 AVC Video Coding
This paper presents different structures that use adaptive -band hierarchical filter banks for temporal scalability. Open-loop and closed-loop co...
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Article
Caspase-1 activation of caspase-6 in human apoptotic neurons
Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Her...
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Chapter
Genetics, molecular biology, and animal modeling of Alzheimer’s disease
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Article
Open AccessLocalised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy
The purpose of this study was to evaluate the efficacy of low-dose chemotherapy in infants with localised and unresectable neuroblastoma (NB). All consecutive infants with localised NB and no N-myc amplification ...
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Article
Open AccessTreatment of stage 4s neuroblastoma – report of 10 years' experience of the French Society of Paediatric Oncology (SFOP)
Stage 4s neuroblastoma (NB) is usually associated with a favourable outcome, despite a large tumour burden, as spontaneous regression frequently occurs. However, in some infants rapid disease progression can b...
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Article
New landmarks improve the positioning of the left Broncho-Cath™ double-lumen tube-comparison with the classic technique
To compare a new technique (NT) for positioning the left modified Broncho-Cath™ double-lumen tube (LM-DLT) by fibreoptic bronchoscopy (FOB) to the classic technique (CT).
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Article
Open AccessLiquid-based cytology for primary cervical cancer screening: a multi-centre study
The aim of this six-centre, split-sample study was to compare ThinPrep fluid-based cytology to the conventional Papanicolaou smear. Six cytopathology laboratories and 35 gynaecologists participated. 5428 patie...
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Article
Open AccessAdverse outcome of infants with metastatic neuroblastoma, MYCN amplification and/or bone lesions: results of the French Society of Pediatric Oncology
To assess the relevance of MYCN amplification and bone lesions in stage 4 neuroblastoma (NB) in infants aged <1 year, 51 infants with stage 4 NB were enrolled. Three groups of patients were defined according t...
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Article
Modeling of a periodic instability in paired helical filaments reveals an axial repeat
Ultrastructural studies of paired helical filaments (PHF) have been facilitated by the ability to isolate enriched fractions of detergent-insoluble forms of PHF. These fractions are composed of a relatively h...
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Article
Membranous nephropathy and orbital malignant tumor
A 7-year-old girl with membranous nephropathy is reported who suffered 16 months later from an orbital rhabdomyosarcoma. Proteinuria disappeared at the time of the remission of the tumor. Membranous nephropath...
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Chapter
Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases
In contrast to rare mutations in the amyloid presursor protein (APP) gene, missense mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, on chromosomes 14 and 1 respectively, are the most common c...
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Article
Feasibility of a PB CD34+ cell transplantation procedure using standard leukapheresis products in very small children
To evaluate the feasibility and efficacy of CD34+ cell immunoselection from routine peripheral blood stem cell (PBSC) harvests in very small children a prospective study was performed in 15 children with advanced...
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Article
Erythrocyte spermine levels: a prognostic parameter in childhood common acute lymphoblastic leukemia
Polyamines have been implicated to play a role in cell proliferation and in cancer development. Ninety percent of the circulating spermidine (Spd) and spermine (Spm) are transported by red blood cells (RBC). R...
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Article
Induction chemotherapy followed by allogeneic bone marrow transplantation or aggressive consolidation chemotherapy in childhood acute myeloblastic leukemia: A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP)
In the LAME89/91 protocol, children with acute myeloid leukemia (AML) who achieved complete remission (CR) after induction chemotherapy, were treated either with allogeneic bone marrow transplantation (BMT) if...
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Chapter and Conference Paper
Comparison Between Allogeneic and Autologous Bone Marrow Transplantation for Childhood Acute Lymphoblastic Leukemia in Second Remission
As a result of steady improvements in chemotherapy over the past 20 years, more than 70% of children with acute lymphoblastic leukemia (ALL) are cured with intensive induction regimens followed by maintenance ...
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Article
Alzheimer paired helical filaments: a comparison with the twisted ribbon model
To investigate if Alzheimer paired helical filaments (PHF) closely resemble twisted ribbons, as indicated by recent high-resolution ultrastructural studies, we compared physical models of twisted ribbons with ...
