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Article
Open AccessPregnant Women’s perceptions of exposure to brominated flame retardants
Recent media reports on human studies associating brominated flame retardants (BFRs) in household products in pregnancy with urogenital anomalies in boys and endocrine disruption in both sexes. We sought to ex...
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Article
Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women
Growth hormone (GH)-deficient individuals display increased adiposity that can be effectively reduced by GH therapy because of GH's lipolytic effects. However, similar GH treatments of individuals with idiopat...
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Article
Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors
In our previous analyses, we found significantly lower levels of growth hormone receptor (GHR) mRNA in adipose tissues of obese than in those of lean individuals, suggesting that idiopathic obesity involves GH re...
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Article
Open AccessFamilial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.
Although familial Alzheimer disease (AD)-associated autosomal dominant mutants have been extensively studied, little is known about the underlying molecular mechanisms of neurodegeneration induced by these mut...
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Article
Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas
Recent studies have demonstrated that in adult murine beta cells the forkhead box O1 (FOXO1) transcription factor regulates proliferation and stress resistance. However, the role of FOXO1 during pancreatic dev...
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Article
Transcription factor expression in the develo** human fetal endocrine pancreas
Morphological changes that occur during pancreatic endocrine cell differentiation have been shown in rodent systems to be dependent on sequential alterations in transcription factor expression. However, simila...
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Article
SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas
In a genome-wide screen using differential methylation hybridization (DMH), we have identified a CpG island within the 5′ region and untranslated first exon of the secretory granule neuroendocrine protein 1 gene ...
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Article
Caspase-1 activation of caspase-6 in human apoptotic neurons
Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Her...
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Article
Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells
Prion protein (PrP) prevents Bcl-2-associated protein X (Bax)-mediated cell death, but the step at which PrP inhibits is not known. We first show that PrP is very specific for Bax and cannot prevent Bak (Bcl-2...
