13 Result(s)

Chapter

Genetics, molecular biology, and animal modeling of Alzheimer’s disease

P. H. St George-Hyslop, P. E. Fraser, D. Westaway… in Alzheimer: 100 Years and Beyond (2006)

Article

Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells

Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-β protein (Aβ) that is central to the pathogenesis of Alzheimer's disease. PS1 regulates the intramembranous proteolysis of a 99-amino-acid...

G Verdile, D Groth, P M Mathews, P St George-Hyslop, P E Fraser… in Molecular Psychiatry (2004)

Article

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis

Immunization of transgenic mouse models of Alzheimer disease using amyloid-β peptide (Aβ) reduces both the Alzheimer disease–like neuropathology and the spatial memory impairments of these mice. However, a the...

J. McLaurin, R. Cecal, M.E. Kierstead, X. Tian, A.L. Phinney, M. Manea… in Nature Medicine (2002)

Chapter and Conference Paper

Further Analysis of the Nicastrin: Presenilin Complex

Nicastrin (Yu et al. 2000) and the presenilins (Rogaev et al. 1995; Sherrington et al. 1995) form high molecular weight complexes that are involved in the cleavage of the β-amyloid precursor protein (βAPP; Citron...

F. Chen, G. Yu, S. Arawaka, M. Nishimura… in Notch from Neurodevelopment to Neurodegene… (2002)

Article

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

The presenilin proteins are components of high–molecular–weight protein complexes in the endoplasmic reticulum and Golgi apparatus that also contain β-catenin. We report here that presenilin mutations associat...

M. Nishimura, G. Yu, G. Levesque, D.M. Zhang, L. Ruel, F. Chen… in Nature Medicine (1999)

Chapter and Conference Paper

Molecular Genetics of the Presenilins in Alzheimer’s Disease

Molecular genetic studies in pedigrees with a reasonably unambiguous single gene autosomal dominant pattern of inheritance have led to the identification of the four different genes associated with inherited s...

P. E. Fraser, G. Yu, G. Levesque, M. Ikeda… in Presenilins and Alzheimer’s Disease (1998)

Chapter

Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases

In contrast to rare mutations in the amyloid presursor protein (APP) gene, missense mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, on chromosomes 14 and 1 respectively, are the most common c...

D. Westaway, G. A. Carlson, C. Bergeron… in Prions and Brain Diseases in Animals and H… (1998)

Article

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence similarity to the S182 gene on chromosome 14q24.3. Mutations, including three new miss...

E. I. Rogaev, R. Sherrington, E. A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang… in Nature (1995)

Article

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic linkage studies have mapped a locus (AD3) associated with susceptibility to a very aggressive form of Alzheimer's disease to...

R. Sherrington, E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda… in Nature (1995)