Immunotoxicology
Proceedings of the International Seminar on the Immunological System as a Target for Toxic Damage — Present Status, Open Problems and Future Perspectives
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Open AccessHigher testosterone is associated with increased inflammatory markers in women with SARS-CoV-2 pneumonia: preliminary results from an observational study
Objective of this study was to assess the association between testosterone (T) levels and biochemical markers in a cohort of female patients admitted for SARS-CoV-2 infection in a respiratory intensive care un...
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High dose chemotherapy and autologous hematopoietic cell transplantation for Wilms tumor: a study of the European Society for Blood and Marrow Transplantation
Survival for subgroups of patients with Wilms tumor (WT), such as those who suffer from relapse, is disappointing. Some patients’ treatment plans include high-dose chemotherapy (HDT) with autologous hematopoie...
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Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy
An intensive therapeutic strategy for metastatic medulloblastoma was launched in 1998 in our Institution. The aim of this study was to examine the long-term quality of life (QoL) in survivor patients at least ...
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Open AccessPossible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster
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Open AccessTreatment and outcome of patients with relapsed clear cell sarcoma of the kidney: a combined SIOP and AIEOP study
Clear cell sarcoma of the kidney (CCSK) is an uncommon paediatric renal tumour. Relapses occur in about 15% of the patients. Since detailed clinical information on relapsed CCSK is scarce, the current study ai...
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Strategie nel trattamento conservativo del piede torto congenito
Clubfoot is one of the most common congenital abnormalities and, therefore, only a proper and early treatment can avoid a permanent deformity.
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Complicazioni negli allungamenti e terapia fisica
Since 1843 external fixation has been performed. Surgical devices progressively evolved, becoming more versatile and safe. Surgical limb lengthening is a widely known technique, but not free from early or bela...
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Trattamento ortopedico con corsetto
Conservative treatment of scoliosis by orthopaedic brace has an indication in cases of moderate or mild scoliosis. Its efficacy is demonstrated through the experience of several orthopaedic schools. The indica...
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Functional inactivation of the WTX gene is not a frequent event in Wilms’ tumors
For many years the precise genetic etiology of the majority of Wilms’ tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately...
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SCT for Wilms’ tumour
Thanks to advances in treatment, approximately 85–90% of patients suffering from Wilms’ tumour are now cured. However, success rate after relapse is significantly lower, ranging from 25 to 45%. Several differe...
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A Case of Relapsing Glioblastoma Multiforme Responding to Vinorelbine
Childhood malignant gliomas are rare and their clinical behavior is almost as aggressive as in adults: they resist treatment, progress rapidly and often spread. Therapeutic strategies at relapse deserve an exp...
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Transitory, spontaneously recovering, peripheral facial nerve palsy after vinorelbine administration
Childhood intrinsic brain-stem gliomas have a dismal prognosis. Different treatment strategies have been adopted over the years without changing the final outcome of this ominous disease. Due to this grim prog...
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Open AccessStage 4 neuroblastoma: sequential hemi-body irradiation or high-dose chemotherapy plus autologous haemopoietic stem cell transplantation to consolidate primary treatment
The aim of the present study was to evaluate the effectiveness of two consecutive nonrandomised treatment programs applied between 1989 and 1999 at the Istituto Nazionale Tumori of Milan in an unselected cohor...
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Case Report: Pseudomonas aeruginosa-related Intervertebral Discitis in a Young Boy with Medulloblastoma
We report a case of a 15-year-old boy with desmoplastic medulloblastoma of the posterior fossa (T3M3, according to Chang classification) incompletely resected, with leptomeningeal and nodular spread in the pos...
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Isolation and characterization of the human A-myb promoter: regulation by NF-Y and Sp1
The A-myb transcription factor shows a restricted tissue distribution and is cell cycle regulated. Furthermore its deregulation has profound effects on the growth and/or differentiation of the cells in which i...
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Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity
Inhibition of angiogenesis through blocking of growth factors involved in this process could be a novel therapeutic approach in several important pathologies, neoplasia among them. Suramin has recently been de...
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In vivo anti-tumour activity of FCE 23762, a methoxymorpholinyl derivative of doxorubicin active on doxorubicin-resistant tumour cells
FCE 23762 is a new doxorubicin derivative obtained by appending a methoxymorpholinyl group at position 3' of the sugar moiety. The compound is greater than 80 times more potent than doxorubicin, it is highly l...
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Book
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Chapter
Immunodepressive Drugs as Prototype Immunotoxicants
In spite of the fact that indisputable advancements have been made in recent years in various areas of immunotoxicology, it can easily be argued that several problems of both conceptual and practical importanc...
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Chapter
Metastatic Potential of Metastases, Tumor Cell Heterogeneity, and Therapeutic Implications
The metastasizing capacity of spontaneous metastases of several murine tumors of different histology, origin, and disseminative pattern was investigated to test the hypothesis that metastases originate from va...
