13 Result(s)
within
Atsushi Yoshiki
Life Sciences
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Article
A hyperthermostable bacterial histone-like protein as an efficient mediator for transfection of eukaryotic cells
Gene delivery has shown potential in a variety of applications, including basic research, therapies for inborn genetic defects, cancer, AIDS, tissue engineering1,2, and vaccination3. Most available systems have s...
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Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice
Non-insulin-dependent diabetes mellitus (NIDDM) is characterized by a breakdown of glucose homeostasis and is responsible for serious complications in various organs and vessels. Most of the genetic factors o...
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Article
Identification of a new target molecule for a cascade therapy of polycystic kidney
Autosomal dominant polycystic kidney disease is a systemic disorder that primary affects the kidney which is characterized by the formation of fluid-filled cysts in both kidneys that leads to progressive renal...
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Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain
MSM/Ms is an inbred mouse strain established from the Japanese wild mouse, Mus musculus molossinus, which has been phylogenetically distinct from common laboratory mouse strains for about 1 million years. The nuc...
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NIG_MoG: a mouse genome navigator for exploring intersubspecific genetic polymorphisms
The National Institute of Genetics Mouse Genome database (NIG_MoG; http://molossinus.lab.nig.ac.jp/msmdb/) primarily comprises the whole-genome sequence data...
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Open AccessReproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study re...
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Open AccessEstablishment and application of information resource of mutant mice in RIKEN BioResource Research Center
Online databases are crucial infrastructures to facilitate the wide effective and efficient use of mouse mutant resources in life sciences. The number and types of mouse resources have been rapidly growing due...
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Open AccessResponse to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”
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Open AccessMouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan
The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division, one of the BRC infrastructure divisions, has been d...
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Open AccessMoG+: a database of genomic variations across three mouse subspecies for biomedical research
Laboratory mouse strains have mosaic genomes derived from at least three major subspecies that are distributed in Eurasia. Here, we describe genomic variations in ten inbred strains: Mus musculus musculus-derived...
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Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific
The Asian Mouse Mutagenesis Resource Association (AMMRA) is a non-profit organization consisting of major resource and research institutions with rodent expertise from within the Asia Pacific region. For more ...
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Open AccessGenetic quality: a complex issue for experimental study reproducibility
Laboratory animal research involving mice, requires consideration of many factors to be controlled. Genetic quality is one factor that is often overlooked but is essential for the generation of reproducible ex...
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Open AccessDevelopment of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging
In vivo bioluminescence imaging (BLI) has been an invaluable noninvasive method to visualize molecular and cellular behaviors in laboratory animals. Bioluminescent reporter mice harboring luciferases for gener...
