13 Result(s)

Article

Validation of [¹⁸F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity

The role of the intestine in the pathogenesis of metabolic diseases is gaining much attention. We therefore sought to validate, using an animal model, the use of positron emission tomography (PET) in the estim...

H. Honka, J. Mäkinen, J. C. Hannukainen, M. Tarkia, V. Oikonen, M. Teräs… in Diabetologia (2013)

Article

Direct effect of GLP-1 infusion on endogenous glucose production in humans

Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, indepe...

M. Seghieri, E. Rebelos, A. Gastaldelli, B. D. Astiarraga, A. Casolaro… in Diabetologia (2013)

Article

Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss.

S. Camastra, A. Gastaldelli, A. Mari, S. Bonuccelli, G. Scartabelli… in Diabetologia (2011)

Article

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients

Both energy restriction (ER) per se and weight loss improve glucose metabolism in obese insulin-treated type 2 diabetic patients. Short-term ER decreases basal endogenous glucose production (EGP) but not gluco...

I. M. Jazet, G. Schaart, A. Gastaldelli, E. Ferrannini, M. K. Hesselink… in Diabetologia (2008)

Article

Visceral fat and beta cell function in non-diabetic humans

Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial.

A. Gastaldelli, A. M. Sironi, D. Ciociaro, V. Positano, E. Buzzigoli… in Diabetologia (2005)

Article

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determine...

E. Bugianesi, A. Gastaldelli, E. Vanni, R. Gambino, M. Cassader, S. Baldi… in Diabetologia (2005)

Article

Reply to Comment on: Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA (2004) Beta cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 43:31–39

A. Gastaldelli, E. Ferrannini, Y. Miyazaki, M. Matsuda, R. A. DeFronzo in Diabetologia (2004)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

Both insulin resistance and beta-cell dysfunction play a role in the transition from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose tolerance (IGT). The aim of the study was ...

A. Gastaldelli, E. Ferrannini, Y. Miyazaki, M. Matsuda, R. A. DeFronzo MD in Diabetologia (2004)

Article

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed.

E. Ferrannini MD, A. Gastaldelli, Y. Miyazaki, M. Matsuda, M. Pettiti… in Diabetologia (2003)

Article

Determinants of postabsorptive endogenous glucose output in non-diabetic subjects

A. Natali, E. Toschi, S. Camastra, A. Gastaldelli, L. Groop, E. Ferrannini in Diabetologia (2000)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)