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  1. No Access

    Article

    Impact of using different biomarkers of liver fibrosis on hepatologic referral of individuals with severe obesity and NAFLD

    The purpose of this study was to estimate how many individuals with severe obesity and NAFLD should be referred to hepatologists according to the EASL–EASD–EASO guidelines and whether the choice of specific in...

    S. Ciardullo, C. Ronchetti, E. Muraca… in Journal of Endocrinological Investigation (2020)

  2. No Access

    Chapter

    NAFLD and Insulin Resistance: A Multisystemic Disease

    NAFLD is an emerging metabolic disease that is affecting almost 25% of the world population. NAFLD is more prevalent in obese subjects or in patients with type 2 diabetes (T2D) where the prevalence is much hig...

    A. Gastaldelli in Non-Alcoholic Fatty Liver Disease (2020)

  3. Article

    Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity

    The role of the intestine in the pathogenesis of metabolic diseases is gaining much attention. We therefore sought to validate, using an animal model, the use of positron emission tomography (PET) in the estim...

    H. Honka, J. Mäkinen, J. C. Hannukainen, M. Tarkia, V. Oikonen, M. Teräs… in Diabetologia (2013)

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  4. Article

    Direct effect of GLP-1 infusion on endogenous glucose production in humans

    Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, indepe...

    M. Seghieri, E. Rebelos, A. Gastaldelli, B. D. Astiarraga, A. Casolaro… in Diabetologia (2013)

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  5. No Access

    Article

    Impact of percent body fat on oral glucose tolerance testing: A cross-sectional study in 1512 obese children

    Background: Although an association between insulin resistance (IR) and body adiposity has been reported in obese children, this relationship has not been studied as thoroughly as in adul...

    G. Bedogni, A. Gastaldelli, F. Agosti… in Journal of Endocrinological Investigation (2012)

  6. Article

    Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

    Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss.

    S. Camastra, A. Gastaldelli, A. Mari, S. Bonuccelli, G. Scartabelli… in Diabetologia (2011)

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  7. No Access

    Article

    Acute effects of gastric bypass versus gastric restrictive surgery on β-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes

    Hyperglycemia resolves quickly after bariatric surgery, but the underlying mechanism and the most effective type of surgery remains unclear.

    S R Kashyap, S Daud, K R Kelly, A Gastaldelli, H Win… in International Journal of Obesity (2010)

  8. Article

    Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients

    Both energy restriction (ER) per se and weight loss improve glucose metabolism in obese insulin-treated type 2 diabetic patients. Short-term ER decreases basal endogenous glucose production (EGP) but not gluco...

    I. M. Jazet, G. Schaart, A. Gastaldelli, E. Ferrannini, M. K. Hesselink… in Diabetologia (2008)

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  9. No Access

    Article

    Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training

    Early-onset type 2 diabetes is associated with marked visceral obesity and extreme insulin resistance, but its pathogenesis and response to treatment are not completely understood. We studied physical fitness,...

    N. Burns, F. M. Finucane, M. Hatunic, M. Gilman, M. Murphy, D. Gasparro… in Diabetologia (2007)

  10. Article

    Visceral fat and beta cell function in non-diabetic humans

    Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial.

    A. Gastaldelli, A. M. Sironi, D. Ciociaro, V. Positano, E. Buzzigoli… in Diabetologia (2005)

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  11. Article

    Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

    Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determine...

    E. Bugianesi, A. Gastaldelli, E. Vanni, R. Gambino, M. Cassader, S. Baldi… in Diabetologia (2005)

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  12. Article

    Reply to Comment on: Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA (2004) Beta cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 43:31–39

    A. Gastaldelli, E. Ferrannini, Y. Miyazaki, M. Matsuda, R. A. DeFronzo in Diabetologia (2004)

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  13. Article

    40th EASD Annual Meeting of the European Association for the Study of Diabetes

    M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

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  14. Article

    Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

    Both insulin resistance and beta-cell dysfunction play a role in the transition from normal glucose tolerance (NGT) to Type 2 diabetes (T2DM) through impaired glucose tolerance (IGT). The aim of the study was ...

    A. Gastaldelli, E. Ferrannini, Y. Miyazaki, M. Matsuda, R. A. DeFronzo MD in Diabetologia (2004)

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  15. Article

    Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

    Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed.

    E. Ferrannini MD, A. Gastaldelli, Y. Miyazaki, M. Matsuda, M. Pettiti… in Diabetologia (2003)

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  16. Article

    Determinants of postabsorptive endogenous glucose output in non-diabetic subjects

    A. Natali, E. Toschi, S. Camastra, A. Gastaldelli, L. Groop, E. Ferrannini in Diabetologia (2000)

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  17. No Access

    Chapter and Conference Paper

    Modelling Interpretation of the Kinetics of Metabolic Processes

    In vivo NMR spectroscopy and sugars selectively enriched with 13C were used to follow the step-by-step metabolic kinetics of microorganisms. A new modelling approach is discussed for the analysis of microbial dyn...

    S. Bastianoni, C. Bonechi, A. Gastaldelli… in Chemistry at the Beginning of the Third Mi… (2000)

  18. Article

    35th Annual Meeting of the European Association for the Study of Diabetes

    A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

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  19. No Access

    Article

    Influence of duration of obesity on the insulin resistance of obese non-diabetic patients

    OBJECTIVE: To investigate whether duration of obesity has an independent impact on insulin resistance.

    E Muscelli, S Camastra, A Gastaldelli, A Natali… in International Journal of Obesity (1998)