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Article
Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genoty** on tissue and liquid biopsies
Resistance to osimertinib in advanced EGFR-mutated non-small cell lung cancer (NSCLC) constitutes a significant challenge for clinicians either in terms of molecular diagnosis and subsequent therapeutic implicati...
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Article
Open AccessErratum: Comparison of HER2 status in primary and paired metastatic sites of gastric carcinoma
Correction to: British Journal of Cancer (2011) 104, 1372–1376. doi:10.1038/bjc.2011.121 Upon publication earlier in Volume 104, the corresponding author noted that one of the co-authors’ names had been incorr...
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Article
Open AccessComparison of HER2 status in primary and paired metastatic sites of gastric carcinoma
Trastuzumab has recently shown efficacy in the treatment of HER2-positive advanced gastric adenocarcinoma. Although antibody-based therapies target the metastatic disease, HER2 status is usually evaluated in t...
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Article
Physiological effects of slee** with the head of the bed elevated 18 in. in young healthy volunteers
Slee** with the head of bed tilted upwards (SHU) is recommended as a treatment of orthostatic hypotension though the supporting evidence is weak.
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Article
Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
Early-onset type 2 diabetes is associated with marked visceral obesity and extreme insulin resistance, but its pathogenesis and response to treatment are not completely understood. We studied physical fitness,...
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Article
Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
Exercise enhances insulin-stimulated glucose transport in skeletal muscle through changes in signal transduction and gene expression. The aim of this study was to assess the impact of acute and short-term exer...
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Article
A case of resistance to thyroid hormone without mutation in the thyroid hormone receptor beta
Resistance to Thyroid Hormone (RTH) is a condition caused by tissue hyposensitivity to the effects of circulating thyroid hormone, and may be misdiagnosed as hyperthyroidism.
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Article
The clinical and metabolic features of Irish patients with acanthosis nigricans
Acanthosis nigricans in Irish subjects is associated with severe obesity and insulin resistance. The analysis highlights that subjects with acanthosis nigricans should be screened for insulin resistance and it...
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Article
The effects of acute and chronic exercise on insulin sensitivity in obesity and type 2 diabetes
Exercise-mediated enhancement of insulin sensitivity is important for the treatment of T2DM. A single bout of exercise accounts for much of the overall improvement, therefore regular exercise is important to m...
