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  1. Article

    Open Access

    The leptin to adiponectin ratio (LAR) is reduced by sleeve gastrectomy in adults with severe obesity: a prospective cohort study

    Bariatric surgery is known to reduce leptin and increase adiponectin levels, but the influence of sleeve gastrectomy on the leptin: adiponectin ratio (LAR), a measure of insulin sensitivity and cardiovascular ...

    M. F. Rafey, C. E. H. Fang, I. Ioana, H. Griffin, M. Hynes… in Scientific Reports (2020)

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  2. Article

    The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial

    We sought to determine the effect of an aerobic exercise intervention on clustered metabolic risk and related outcomes in healthy older adults in a single-centre, explanatory randomised controlled trial.

    F. M. Finucane, S. J. Sharp, L. R. Purslow, K. Horton, J. Horton… in Diabetologia (2010)

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  3. Article

    Open Access

    Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals

    Obesity is the dominant cause of insulin resistance. In adult humans it is characterised by a combination of adipocyte hypertrophy and, to a lesser extent, adipocyte hyperplasia. As hypertrophic adipocytes sec...

    F. M. Finucane, J. Luan, N. J. Wareham, S. J. Sharp, S. O’Rahilly… in Diabetologia (2009)

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  4. No Access

    Article

    Obesity in Irish youth: epidemiology and implications

    The worldwide epidemic of type 2 diabetes has been paralleled by a marked increase in the prevalence of obesity, particularly in younger people. This will contribute significantly to the future burden of cardi...

    F. M. Finucane in Irish Journal of Medical Science (2009)

  5. No Access

    Article

    Elevated blood pressure in overweight and obese Irish children

    The Irish childhood obesity epidemic, one of the highest ranking internationally, represents a major threat to public health. We sought to perform a retrospective observational study of a clinic based cohort o...

    F. M. Finucane, S. Pittock, M. Fallon, M. Hatunic… in Irish Journal of Medical Science (2008)

  6. No Access

    Article

    Propylthiouracil induced C-ANCA positive agranulocytosis complicating Graves’ thyrotoxicosis in pregnancy

    Thionamide induced agranulocytosis is associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in some patients. This poses a particular challenge when it occurs during pregnancy.

    F. M. Finucane, J. O’Connell, B. T. Kinsley in Irish Journal of Medical Science (2008)

  7. No Access

    Article

    Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training

    Early-onset type 2 diabetes is associated with marked visceral obesity and extreme insulin resistance, but its pathogenesis and response to treatment are not completely understood. We studied physical fitness,...

    N. Burns, F. M. Finucane, M. Hatunic, M. Gilman, M. Murphy, D. Gasparro… in Diabetologia (2007)