-
Article
Open AccessImpact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function
The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology and function remain unclear. In the current study, we examined to what extent physical...
-
Article
Muscle fiber-type distribution, fiber-type-specific damage, and the Pompe disease phenotype
Pompe disease is a lysosomal storage disorder caused by acid α-glucosidase deficiency and characterized by progressive muscle weakness. Enzyme replacement therapy (ERT) has ameliorated patients’ perspectives, ...
-
Article
Open AccessDifferential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice
In conditions of continuous high-fat (HF) intake, the degree of saturation of the fatty acids (FAs) in the diet might have a crucial role in the onset of obesity and its metabolic complications. In particular,...
-
Article
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
Both energy restriction (ER) per se and weight loss improve glucose metabolism in obese insulin-treated type 2 diabetic patients. Short-term ER decreases basal endogenous glucose production (EGP) but not gluco...
-
Article
Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
To examine whether rosiglitazone alters gene expression of some key genes involved in mitochondrial biogenesis and oxidative capacity in skeletal muscle of type 2 diabetic patients, and whether this is associa...
-
Article
UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects
Uncoupling protein 3 (UCP3) is a muscle mitochondrial protein believed to uncouple the respiratory chain, producing heat and reducing aerobic ATP production. Our aim was to quantify and compare the UCP3 prote...
-
Article
The effect of mild cold exposure on UCP3 mRNA expression and UCP3 protein content in humans
OBJECTIVE: In rodents, adaptive thermogenesis in response to cold exposure and high-fat feeding is accomplished by the activation of the brown adipose tissue specific mitochondrial uncoupling protein, UCP1. The r...
-
Article
The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects
Aims/hypothesis. The aim of this study was to examine the effect of weight loss on UCP2/UCP3 mRNA expression and UCP3 protein content in subjects with Type II (non-insulin-dependent) diabetes mel...
-
Article
35th Annual Meeting of the European Association for the Study of Diabetes
-
Article
Expression and organization of muscle specific proteins during the early developmental stages of the rabbit heart
The expression and intracellular distribution patterns of muscle-specific proteins were studied during rabbit embryo development (7–13 dpc) using monoclonal antibodies against titin, myosin, tropomyosin and ac...
-
Chapter
Cytoskeletal Proteins as Markers in Surgical Pathology.
Within the cytoskeleton of the cell three different types of filaments can be distinguished on basis of their ultrastructural appearance and biochemical composition. Next to microfilaments and microtubules, fi...
