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Article
Open AccessDurvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin
Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual checkpoint blockade may improve treatment activity. Dune (NCT03095274) is a non-randomized controlled ...
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Article
Cognitive performance of people with traumatic spinal cord injury: a cross-sectional study comparing people with subacute and chronic injuries
Cross-sectional study.
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Article
An internally validated new clinical and inflammation-based prognostic score for patients with advanced hepatocellular carcinoma treated with sorafenib
Sorafenib is a standard treatment for patients (pts) with advanced hepatocellular carcinoma (aHCC), although the clinical benefit is heterogeneous between different pts groups. Among novel prognostic factors, ...
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Article
Translational research in neuroendocrine tumors: pitfalls and opportunities
Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have become one o...
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Living Reference Work Entry In depth
Pathways for the Degradation of Fatty Acids in Bacteria
The metabolism of fatty acids is of central importance to wide range of microbes, and the related metabolic pathways have been intensely studied for decades. Fatty acid degradation occurs through the well-char...
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Reference Work Entry In depth
Genetics of Accessing and Exploiting Hydrocarbons
Hydrocarbons abound in the environment and microorganisms are often capable of assimilating and degrading these normally recalcitrant molecules. In order to achieve this, bacteria have developed specific adapt...
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Reference Work Entry In depth
Extrusion Pumps for Hydrocarbons: An Efficient Evolutionary Strategy to Confer Resistance to Hydrocarbons
Efflux pumps of the RND family are primarily involved in the extrusion of hydrocarbons. These pumps, specific to gram-negative bacteria, are composed of three components. Two components are transmembrane prote...
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Reference Work Entry In depth
Removal of Hydrocarbons and Other Related Chemicals via the Rhizosphere of Plants
Recalcitrant organic toxic chemicals have accumulated for decades as a consequence of industrial activity. The use of plants in bioremediation of soils has been proposed as an attractive strategy however, plan...
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Reference Work Entry In depth
Protocols for the Characterization of Solvent Tolerant Microorganisms: Construction and Characterization of Mutants
A number of microorganisms exhibit the unusual property of being tolerant to high concentrations of organic solvents such as toluene, xylenes, ethylbenzene, 1-octanol, 1-decanol, etc. in the culture medium. Th...
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Reference Work Entry In depth
Membrane Composition and Modifications in Response to Aromatic Hydrocarbons in Gram Negative Bacteria
Bacterial cells are surrounded by a cellular envelope composed of the cytoplasmic membrane and the cell wall. The cytoplasmic membrane is a phospholipid bilayer that provides an appropriate matrix for the func...
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Article
Improved somatic embryogenesis of grapevine (Vitis vinifera) with focus on induction parameters and efficient plant regeneration
A study of four parameters (induction medium, floral explant, developmental stage and year) was carried out to determine the best combination for the embryogenesis induction of eight grapevine (Vitis vinifera L.)...
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Article
Policy for the Management of the Pharmacovigilance Unified system in the Province Of Cordoba (SUFV)
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Article
Cefepime monotherapy as an empirical initial treatment of patients with febrile neutropenia
Currently, monotherapy is considered a valid alternative to the combination antibiotic treatments used for initial, empirical management of febrile neutropenia. The advent of new cephalosporins warrants assess...
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Article
Long-term results after combined modality treatment for non-metastatic osteosarcoma
Since the introduction of multimodality treatment, the prognosis of patients with high-grade non-metastatic osteosarcoma has significantly improved. A retrospective review was performed to assess the long-term...
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Chapter
Wide Binaries in the Hyades Cluster
With the purpose of studying the time evolution of the distribution of separations of binary systems, a long term effort is being made to obtain homogeneous samples of binaries of different ages. In this work,...
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Article
Ultrastructure of chloroplasts of pine needles exposed to an industrial environment
In one- and two-year-old green needles ofPinus pinaster growing downwind from a coal-fired power station (main airborne pollutant SO2), mesophyll chloroplast alterations consisted in swelling of the lamellae (ran...
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Article
Time resolved photoluminescence of Cd-doped InSe
High resolution and time resolved photoluminescence in low resistivity Cd dopedp-type InSe in the 32K–155K temperature range are reported. The photoluminescence spectra consist of a broad band that turns out to h...
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Article
Transport properties of silicon doped n-indium selenide
Hall effect and resistivity measurements in silicon doped indium selenide (InSe), from 7K to 500K, are reported. Results are interpreted through a model, previously proposed for tin doped InSe, that takes into...
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Article
Positrons and electron-irradiation induced defects in the layered semiconductor InSe
The positron annihilation characteristics of the layered semiconductor InSe have been investigated. No evidence for low temperature positron trap** is found in as-grown and heavily deformed InSe. The tempera...
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Article
Deep level transient spectroscopy measurement on tin-doped n-indium selenide
Deep level transient spectroscopy measurements in indium selenide samples doped with different amounts of tin are reported. Three tin-related electron traps have been detected with activation energies for emis...
