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    Chapter and Conference Paper

    Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact

    Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...

    O. W. Sakowitz, C. Schardt, M. Neher, J. F. Stover, A. W. Unterberg… in Brain Edema XIII (2006)

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    Chapter and Conference Paper

    Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats

    Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.

    J. F. Stover M.D, O. W. Sakowitz… in Mechanisms of Secondary Brain Damage from … (2004)

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    Chapter and Conference Paper

    Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury

    We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...

    Asita S. Sarrafzadeh, O. W. Sakowitz… in Intracranial Pressure and Brain Biochemica… (2002)

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    Chapter and Conference Paper

    Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats

    Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...

    S.-N. Kroppenstedt, O. W. Sakowitz… in Intracranial Pressure and Brain Biochemica… (2002)

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    Chapter and Conference Paper

    Neuronal Activity Determined by Quantitative EEG and Cortical Microdialysis is Increased Following Controlled Cortical Impact Injury in Rats

    Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalo-graphic (...

    O. W. Sakowitz, A. W. Unterberg… in Intracranial Pressure and Brain Biochemica… (2002)

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    Chapter and Conference Paper

    Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by on-Line Microdialysis

    Subarachnoid hemorrhage (SAH) is one of the most devastating of all cerebrovascular disorders [10]. One of the most serious complications of SAH remains vasospasm [3, 9]. Bedside cerebral microdialysis is a recen...

    A. S. Sarrafzadeh, O. W. Sakowitz, W. R. Lanksch, A. W. Unterberg in Cerebral Vasospasm (2001)