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Chapter and Conference Paper
Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations
Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...
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Chapter and Conference Paper
Serial diffusion and perfusion MRI analysis of the perihemorrhagic zone in a rat ICH model
Cerebral ischemia has been proposed as a contributing mechanism to secondary neuronal injury after intracranial hemorrhage (ICH). We aimed to examine perihemorrhagic changes with an animal experimental MRI stu...
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Chapter and Conference Paper
Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact
Granulocyte colony-stimulating factor (G-CSF) is an established treatment in the neutropenic host. Usage in headinjured patients at risk for infection may aggravate brain damage. In contrast, evidence of G-CSF...
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Chapter and Conference Paper
Neuronal activity and cortical perfusion determined by quantitative EEG analysis and laser Doppler flowmetry are uncoupled in brain injured rats
Following traumatic brain injury uncoupling of metabolism from perfusion, reflected by an increase in cellular activity in face of reduced perfusion contributes to secondary tissue damage.
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Chapter and Conference Paper
Detection of Secondary Insults by Brain Tissue pO2 and Bedside Microdialysis in Severe Head Injury
We evaluated bedside cerebral on-line microdialysis for early detection of cerebral hypoxia in patients with traumatic brain injury. 24 severely head injured patients (Glasgow Coma Score ≤ 8) were studied. Pat...
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Chapter and Conference Paper
Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats
Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perf...
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Chapter and Conference Paper
Neuronal Activity Determined by Quantitative EEG and Cortical Microdialysis is Increased Following Controlled Cortical Impact Injury in Rats
Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalo-graphic (...
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Chapter and Conference Paper
Time Course of Various Interstitial Metabolites Following Subarachnoid Hemorrhage Studied by on-Line Microdialysis
Subarachnoid hemorrhage (SAH) is one of the most devastating of all cerebrovascular disorders [10]. One of the most serious complications of SAH remains vasospasm [3, 9]. Bedside cerebral microdialysis is a recen...