12 Result(s)
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Article
Yoshikazu Johmura
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Open AccessPlasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts
Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. In...
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LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits
Protein misfolding is a major factor of neurodegenerative diseases. Post-mitotic neurons are highly susceptible to protein aggregates that are not diluted by mitosis. Therefore, post-mitotic cells may have a s...
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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulat...
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Open AccessAlteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance
Sacituzumab govitecan is an antibody–drug conjugate that delivers SN-38, an active metabolite of irinotecan, to the target molecule, trophoblast cell-surface antigen 2 (Trop-2). It is a promising drug for trip...
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Open AccessCdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained at a constant lev...
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Open AccessUsp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation
Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to DNA methylation sites. However, the involvement of...
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Open AccessA combination of genetic and biochemical analyses for the diagnosis of PI3K-AKT-mTOR pathway-associated megalencephaly
Constitutive activation of the PI3K-AKT-mTOR pathway (mTOR pathway) underlies megalencephaly in many patients. Yet, prevalence of the involvement of the PI3K-AKT-mTOR pathway in patients with megalencephaly re...
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Open AccessDefective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation
Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknow...
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Open AccessEssential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
Proper deposition and activation of Aurora B at the centromere is critical for faithful chromosome segregation in mammals. However, the mechanistic basis for abrupt Aurora B kinase activation at the centromere...
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Open AccessSCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly establ...
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Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
The RING finger domain protein Uhrf1 is known to have an important role in DNA methylation pattern maintenance through the recruitment of the methyltransferase Dnmt1 to hemimethylated DNA sites: here, Uhrf1 is...
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Polo-box domain: a versatile mediator of polo-like kinase function
Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo...
