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Open AccessCalcineurin regulates cyclin D1 stability through dephosphorylation at T286
The Calcineurin/NFAT (nuclear factor of activated T cells) pathway plays an essential role in the tumorigenic and metastatic properties in breast cancer. The molecular mechanism of the antiproliferative effect...
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Open AccessEssential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
Proper deposition and activation of Aurora B at the centromere is critical for faithful chromosome segregation in mammals. However, the mechanistic basis for abrupt Aurora B kinase activation at the centromere...
