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  1. No Access

    Article

    Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes

    The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulat...

    Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita… in Nature (2022)

  2. Article

    Open Access

    Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo

    The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) axis is an essential regulator of angiogenesis and important therapeutic target in cancer. Ramucirumab is an anti-VEGFR2 monoclonal antibody ...

    Tetsuo Mashima, Takeru Wakatsuki, Naomi Kawata, Myung-Kyu Jang… in Scientific Reports (2021)

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  3. Article

    Open Access

    In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells

    Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established.

    Tetsuo Mashima, Risa Iwasaki, Naomi Kawata, Ryuhei Kawakami… in British Journal of Cancer (2019)

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  4. No Access

    Article

    SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1

    Genetic mutations of steroidogenic factor 1 (also known as Ad4BP or Nr5a1) have increasingly been reported in patients with 46,XY disorders of sex development (46,XY disorders of sex development). However, becaus...

    Megumi Hatano, Toshiro Migita, Tomokazu Ohishi, Yuichi Shima, Yoshihiro Ogawa… in Endocrine (2016)