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  1. No Access

    Article

    Discovery of a structural class of antibiotics with explainable deep learning

    The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1–9. Deep learning approaches have aided in exploring chemical spaces1,10–15; these t...

    Felix Wong, Erica J. Zheng, Jacqueline A. Valeri, Nina M. Donghia… in Nature (2024)

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    Article

    Discovering small-molecule senolytics with deep neural networks

    The accumulation of senescent cells is associated with aging, inflammation and cellular dysfunction. Senolytic drugs can alleviate age-related comorbidities by selectively killing senescent cells. Here we scre...

    Felix Wong, Satotaka Omori, Nina M. Donghia, Erica J. Zheng… in Nature Aging (2023)

  3. No Access

    Article

    Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes

    The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulat...

    Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita… in Nature (2022)