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Article
Open AccessContinuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...
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Article
Open AccessTime space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages ...
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Article
Open AccessBase editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation
During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...
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Article
Open AccessGeneration of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...
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Article
Open AccessThe therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obs...
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Article
Open AccessAuthor Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation
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Article
Open AccessFormative pluripotent stem cells show features of epiblast cells poised for gastrulation
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotenc...
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAccelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies
Social hierarchies emerged during evolution, and social rank influences behavior and health of individuals. However, the evolutionary mechanisms of social hierarchy are still unknown in amniotes. Here we devel...
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessA secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. A...
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Article
Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Article
Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland
In the initial published version of this article, there was a mistake in one author name (**gsong Li). The correct name should be “**song Li”. This correction does not affect the description of the results o...
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Author Correction: Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction
In the version of this article initially published, the following grant numbers and recipients were missing from the Acknowledgements: XDB19000000 to H.J. and B.Z.; 81430066 and 31621003 to H.J.; 2017YFA050550...
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Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
In the version of this Article originally published, the first name of author Guangdun Peng was spelled incorrectly as Guangdum. This has now been amended in all versions of the Article.
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Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions...
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Open AccessAuthor Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessInference of differentiation time for single cell transcriptomes using cell population reference data
Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often ...
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Article
Open AccessAbnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
The paraventricular nucleus of hypothalamus plays important roles in the regulation of energy balance and fetal growth. However, the molecular mechanisms underlying its formation and function have not been cle...
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Article
CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development
Studying the early function of essential genes is an important and challenging problem in developmental biology. Here, we established a method for rapidly inducing CRISPR-Cas9-mediated mutations in one blastom...