22 Result(s)
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M. Keith Sharp
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Open AccessPulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance
A glymphatic system has been proposed that comprises flow that enters along cerebral paraarterial channels between the artery wall and the surrounding glial layer, continues through the parenchyma, and then ex...
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Open AccessIn vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy
Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investig...
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Deformation of human red blood cells in extensional flow through a hyperbolic contraction
Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements o...
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Solvent-based bonding of PMMA–PMMA for microfluidic applications
Solvent bonding is a simple, inexpensive and quick technique used for joining microfluidic parts made of thermoplastic polymers that results in high bonding strength and good optical clarity. However, selectin...
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Modeling and prediction of flow-induced hemolysis: a review
Despite decades of research related to hemolysis, the accuracy of prediction algorithms for complex flows leaves much to be desired. Fundamental questions remain about how different types of fluid stresses tra...
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Open AccessDispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between...
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Open AccessIs bulk flow plausible in perivascular, paravascular and paravenous channels?
Transport of solutes has been observed in the spaces surrounding cerebral arteries and veins. Indeed, transport has been found in opposite directions in two different spaces around arteries. These findings hav...
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Characterization of erythrocyte membrane tension for hemolysis prediction in complex flows
Hemolysis is a persistent issue with blood-contacting devices. Many experimental and theoretical contributions over the last few decades have increased insight into the mechanisms of hemolysis in both laminar ...
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Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients
Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to...
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Erratum to: Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells
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Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells
This study demonstrated the effects of the directionality of oscillatory wall shear stress (WSS) on proliferation and proatherogenic gene expression (I-CAM, E-Selectin, and IL-6) in the presence of inflammator...
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Peristalsis with Oscillating Flow Resistance: A Mechanism for Periarterial Clearance of Amyloid Beta from the Brain
Alzheimer’s disease is characterized by accumulation of amyloid-β (Aβ) in the brain and in the walls of cerebral arteries. The focus of this work is on clearance of Aβ along artery walls, the failure of which may...
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Space physiology IV: mathematical modeling of the cardiovascular system in space exploration
Mathematical modeling represents an important tool for analyzing cardiovascular function during spaceflight. This review describes how modeling of the cardiovascular system can contribute to space life science...
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Maximizing information from space data resources: a case for expanding integration across research disciplines
Regulatory systems are affected in space by exposure to weightlessness, high-energy radiation or other spaceflight-induced changes. The impact of spaceflight occurs across multiple scales and systems. Explorin...
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Apical-Ventricular Cannula for Aortic Valve Bypass Therapy
A growing number of elderly patients with significant co-morbidities do not meet the inclusion criteria for conventional cardiac surgical therapies, including aortic valve replacement and mechanical circulator...
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Open AccessAccuracy of flow measurement with phase contrast MRI in a stenotic phantom: where should flow be measured?
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Simulated Stand Tests and Centrifuge Training to Prevent Orthostatic Intolerance on Earth, Moon, and Mars
One proposed method to overcome postflight orthostatic intolerance is for astronauts to undergo inflight centrifugation. Cardiovascular responses were compared between centrifuge and gravitational conditions u...
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Evaluation of Mechanisms of Postflight Orthostatic Intolerance with a Simple Cardiovascular System Model
A significant fraction of astronauts experience postflight orthostatic intolerance (POI) during 10-min stand tests conducted on landing day. The average time that nonfinishers can stand is about 7 min. This ph...
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Numerical Simulation of the Influence of Gravity and Posture on Cardiac Performance
A numerical model of the cardiovascular system was used to quantify the influences on cardiac function of intrathoracic pressure and intravascular and intraventricular hydrostatic pressure, which are fundament...
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Influence of Gravity on Cardiac Performance
Results obtained by the investigators in ground-based experiments and in two parabolic flight series of tests aboard the NASA KC-135 aircraft with a hydraulic simulator of the human systemic circulation have c...
