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  1. Article

    Open Access

    Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

    Intrathecal drug delivery has a significant role in pain management and central nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in choosing specific drug doses to the...

    Mohammadreza Khani, Goutham Kumar Reddy Burla… in Fluids and Barriers of the CNS (2022)

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  2. Article

    Open Access

    In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy

    Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investig...

    Mohammadreza Khani, Lucas R. Sass, M. Keith Sharp… in Fluids and Barriers of the CNS (2020)

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  3. Article

    Open Access

    Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

    Develo** novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due t...

    Lucas R. Sass, Mohammadreza Khani, Jacob Romm… in Fluids and Barriers of the CNS (2020)

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  4. Article

    Open Access

    A 3D subject-specific model of the spinal subarachnoid space with anatomically realistic ventral and dorsal spinal cord nerve rootlets

    The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry with multiple levels of anatomic complexity, the most salient features being the spinal cord and dorsal and ventral nerve rootlets. An...

    Lucas R. Sass, Mohammadreza Khani… in Fluids and Barriers of the CNS (2017)

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