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Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients

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Abstract

Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to providing circulatory support and surgical therapies for pediatric and adult patients, viscous and elastic components of complex blood viscoelasticity of 31 pediatric patients were compared to those of 29 adult patients with a Vilastic-3 rheometer. A random effects model with categorical age covariates found statistically significant differences between pediatric and adult patients for log viscosity (p = 0.005). Log strain (p < 0.0001) and hematocrit (p < 0.0001) effects were also significant, as were the hematocrit-by-log-strain (p = 0.0006) and age-by-log strain (p = 0.001) interactions. The hematocrit-by-age interaction was not significant. For log elasticity, age differences were insignificant (p = 0.39). The model for log elasticity had significant log strain (p < 0.0001), log strain squared (p < 0.0001) and hematocrit (p < 0.0001) effects, as well as hematocrit-by-log-strain and hematocrit-by-log-strain-squared interactions (p = 0.014). A model for log viscosity with continuous age was also fit to the data, which can be used to refine cardiovascular device design and operation to the age of the patient. We conclude that there are distinct differences between pediatric and adult blood viscosity, as well as substantial variation within the pediatric population, that may impact the performance of devices and procedures.

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Acknowledgments

We would like to express our appreciation to the patients who were willing to participate in this investigation and to students who provided technical assistance in the evaluation of the blood samples.

Conflict of Interest

Sharp, Gregg, Brock, Nair, Sahetya, Austin, Mascio, Slaughter, and Pantalos declare no conflicts of interest.

Funding

This project was provided by the National Institutes of Health Heart, Lung and Blood Institute (Grant 2 R44 HL059810 and Contract No. HHSN268200449189C), the Jewish Hospital & St. Mary’s Foundation (Louisville, KY), and Kosair Charities, Louisville, KY.

Human and Animal Studies

Human studies were performed in accordance with Institutional Review Board and Helsinki standards. No animals were involved.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Louisville, 200 Sackett Hall, Louisville, KY, 40292, USA

    M. Keith Sharp & Neema Nair

  2. School of Public Health, University of Louisville, Louisville, KY, USA

    Mary Gregg & Guy Brock

  3. Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA

    Sarina Sahetya & George M. Pantalos

  4. Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, KY, USA

    Erle H. Austin III, Christopher Mascio, Mark D. Slaughter & George M. Pantalos

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  1. M. Keith Sharp
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Correspondence to M. Keith Sharp.

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Associate Editors Keefe B. Manning and Ajit P. Yoganathan oversaw the review of this article.

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Sharp, M.K., Gregg, M., Brock, G. et al. Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients. Cardiovasc Eng Tech 8, 182–192 (2017). https://doi.org/10.1007/s13239-017-0300-7

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