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Article
Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring
Between 1982 and 1991, 41 patients were treated for non HIV related primary cerebral lymphoma (PCL) in our institute. The purpose of this study was to perform a multivariate analysis of prognostic factors for ...
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Article
Tolerance Evaluation of L-asparaginase loaded in red blood cells
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Article
Correlation between clinical response to interleukin 2 and HLA phenotypes in patients with metastatic renal cell carcinoma
HLA phenotypes were characterized for 79 patients with metastatic renal cell carcinoma treated with interleukin 2 (IL-2). HLA-A32 was associated with a clinical response (P = 0.025). The frequency of HLA-A3 an...
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Article
High-dose chemotherapy with hematopoietic stem cell transplantation in patients with mantle cell or diffuse centrocytic non-Hodgkin’s lymphomas: a single center experience on 18 patients
Between 1985 and 1996, 18 patients with diffuse centrocytic lymphoma (DCL), including nine patients with an established histological and phenotypic diagnosis of mantle cell lymphoma (MCL), received 19 courses ...
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Article
Open AccessRenal cell carcinoma induces interleukin 10 and prostaglandin E2 production by monocytes
Immunotherapy with interleukin 2 (IL-2) is not an effective anti-cancer treatment in the majority of patients with renal cell carcinoma (RCC), suggesting that the activation of cytotoxic T cells or NK cells ma...
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Article
Assessment of osteosarcoma response to neoadjuvant chemotherapy: comparative usefulness of dynamic gadolinium-enhanced spin-echo magnetic resonance imaging and technetium-99 m skeletal angioscintigraphy
The aim of this work was to study and compare the usefulness of dynamic contrast-enhanced spin-echo MR imaging with high temporal resolution hydroxymethylene diphosphonate technetium-99 m skeletal angioscinti...
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Article
Research controversies in management of oral mucositis
The management of mucositis is the subject of many controversies, and the optimal treatment is still not known. Several evaluation scoring systems have been described, but no one of these is appropriate to al...
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Article
Open AccessOsteosarcoma
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Article
Open AccessIdentification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas
1–5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study w...
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Article
Open AccessA phase I/II study of 4 monthly courses of high-dose cyclophosphamide and thiotepa for metastatic breast cancer patients
This pilot phase I/II study intended to determine the maximum tolerated dose of cyclophosphamide and thiotepa administered on four consecutive courses with peripheral blood progenitor cell and granulocyte-colo...
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Article
Open AccessBaseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy
A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters availa...
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Article
Open AccessPrognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients
Prediction of survival for patients with metastatic breast cancer is often inaccurate and may be helped by new biological parameters. Tumour growth being angiogenesis-dependent, it has been hypothesised that t...
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Article
Actualité de l’ASCO 2004 par localisations
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Article
Tumeurs rares malignes de l’ovaire
Les tumeurs rares de la sphère ovarienne adulte représentent moins de 10 % des tumeurs ovariennes de l’adulte. Le traitement des tumeurs rares de l’ovaire est actuellement établi comme suit:
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Article
Dendritic cells are essential for priming but inefficient for boosting antitumour immune response in an orthotopic murine glioma model
The prognosis of malignant gliomas remains dismal and alternative therapeutic strategies are required. Immunotherapy with dendritic cells (DCs) pulsed with tumour antigens emerges as a promising approach. Many...
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Article
Open AccessAutoantibodies to endostatin in patients with breast cancer: correlation to endostatin levels and clinical outcome
Circulating autoantibodies to self-antigens overexpressed by cancer cells are common in cancer patients. As specific proteins are expressed during neoangiogenesis, a similar phenomenon might occur with particu...
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Article
Le traitement des causes du cancer
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Article
Anticorps anti-VEGF: un emploi universel?
Il y a 25 ans, la convergence de plusieurs stratégies de recherches indépendantes vers un petit nombre de gènes a permis de fonder le paradigme des oncogènes, les «gènes de cancer» dont les dé règlements pertu...
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Article
Open AccessIncidence and prognostic value of tumour cells detected by RT–PCR in peripheral blood stem cell collections from patients with Ewing tumour
To retrospectively evaluate the incidence of tumour cell contamination of peripheral blood stem cell (PBSC) collections and to correlate these data with the clinical outcome after high-dose chemotherapy (HDCT)...
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Article
Nouvelles approches dans les thérapeutiques ciblées: les récepteurs des facteurs de croissance de type insuline et les cyclines
Le spectre des thérapies ciblées s'est élargi avec le ciblage de l'insulin-like growth factor (IGF1R) ou des cyclines. L'IGF1R est impliqué dans la prolifération tumorale et la résistance à l'apoptose. Des antico...
