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  1. No Access

    Article

    Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in human prostate cancer cells

    The expression of telomerase in human cells is strictly controlled by multiple mechanisms including transcription and alternative splicing of telomerase reverse transcriptase (hTERT). In this study, we demons...

    C. Brambilla, M. Folini, P. Gandellini… in Cellular and Molecular Life Sciences CMLS (2004)

  2. Article

    E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIPshort

    E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously postulated that the low level of E2F1 in primary lung adenocarcinoma contributes to ...

    C Salon, B Eymin, O Micheau, L Chaperot, J Plumas… in Cell Death & Differentiation (2006)

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    Article

    E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors

    The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated th...

    C Salon, G Merdzhanova, C Brambilla, E Brambilla, S Gazzeri, B Eymin in Oncogene (2007)

  4. Article

    E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

    The transcription factor E2F1 has a key function during S phase progression and apoptosis. It has been well-demonstrated that the apoptotic function of E2F1 involves its ability to transactivate pro-apoptotic ...

    G Merdzhanova, V Edmond, S De Seranno, A Van den Broeck… in Cell Death & Differentiation (2008)

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    Article

    Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

    Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly...

    C Caron, C Lestrat, S Marsal, E Escoffier, S Curtet, V Virolle, P Barbry… in Oncogene (2010)

  6. No Access

    Article

    The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

    The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular en...

    G Merdzhanova, S Gout, M Keramidas, V Edmond, J-L Coll, C Brambilla… in Oncogene (2010)

  7. No Access

    Article

    Sumoylation of ING2 regulates the transcription mediated by Sin3A

    ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence. Although the functions of ING2 within the chromatin remodeling complex Sin3A/histone ...

    D Ythier, D Larrieu, R Binet, O Binda, C Brambilla, S Gazzeri, R Pedeux in Oncogene (2010)