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Open AccessSocial amoebae trap and kill bacteria by casting DNA nets
Extracellular traps (ETs) from neutrophils are reticulated nets of DNA decorated with anti-microbial granules, and are capable of trap** and killing extracellular pathogens. Various phagocytes of mammals and...
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Article
Open AccessA new social gene in Dictyostelium discoideum, chtB
Competitive social interactions are ubiquitous in nature, but their genetic basis is difficult to determine. Much can be learned from single gene knockouts in a eukaryote microbe. The mutants can be competed w...
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Open AccessComparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk ce...
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Open AccessNew components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data
Identifying candidate genes in genetic networks is important for understanding regulation and biological function. Large gene expression datasets contain relevant information about genetic networks, but mining...
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Article
Open AccessConserved developmental transcriptomes in evolutionarily divergent species
Evolutionarily divergent organisms often share developmental anatomies despite vast differences between their genome sequences. The social amoebae Dictyostelium discoideum and Dictyostelium purpureum have similar...
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Article
Cheater-resistance is not futile
Individual social amoebae such as Dictyostelium must cooperate to build the fruiting bodies through which they reproduce. As with all societies, this process is highly susceptible to cheats who reap the benefits ...
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Open AccessdictyExpress: a Dictyostelium discoideum gene expression database with an explorative data analysis web-based interface
Bioinformatics often leverages on recent advancements in computer science to support biologists in their scientific discovery process. Such efforts include the development of easy-to-use web interfaces to biom...
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Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae
The evolution of cooperation is central to the transition by organisms from unicellular to multicellular states. Mutant cells that 'cheat' by benefiting from the cooperation of others but offering nothing in r...
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Open AccessHigh-throughput analysis of spatio-temporal dynamics in Dictyostelium
We demonstrate a time-lapse video approach that allows rapid examination of the spatio-temporal dynamics of Dictyostelium cell populations. Quantitative information was gathered by sampling life histories of more...
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Article
Epistasis analysis with global transcriptional phenotypes
Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a varie...
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Article
Sequence and analysis of chromosome 2 of Dictyostelium discoideum
The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despit...
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Article
The promise of a protist: the Dictyostelium genome project
The genome of Dictyostelium discoideum is being sequenced by an international consortium and is scheduled for completion in the next few years. The sequence will accelerate research into a number of phenomena ca...