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Synthesis and Evaluation of the Biological Activity of New Succinimides Substituted at the Nitrogen Atom with Benzenesulfonamides
A series of pyrrolidine-2.5-diones with benzenesulfonamide substituents on the ring N atom were synthesized from substituted dicarboxylic acids and...
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Comparative Evaluation of Alternative Deblocking Agents to Piperidine for Solid-Phase Synthesis of Peptides
The availability of piperidine, which is widely used for deblocking α-amine groups in solid-phase peptide synthesis using Fmoc methodology, is now...
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Synthetic Low-Molecular-Mass Compounds as Potential Inhibitors of Staphylococcus Aureus Adhesion in Experiment
Decreased adhesion of Staphylococcus aureus provides additional opportunities for the prevention and treatment of infectious diseases caused by...
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CU(II) Complex with Nicotine and Carcinogenicity of Raw Medical Tobacco
Unusual coordination of Cu(II) with the pyrrolidine N atom of nicotine in aqueous solution that could promote the formation of carcinogenic N -nitroson...
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Synthesis and Antiarrhythmic, Hemostatic, Anthelmintic, and Larvicidal Activity of (3,3-Dialkyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)Acetamide Hydrochlorides
A series of (3,3-dialkyl-6,7-diethoxy-3,4-dihydroisoquinolin-1(2 H )-ylidene)acetamide hydrochlorides were synthesized via Ritter cyclocondensation of...
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Acute Toxicity and Analgesic Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones
The acute toxicity and analgesic activity of six compounds of the 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-one series were studied....
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Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochlorides
N,N ' -bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, P1, P4 – P8, and R1 – R7, were assayed against human oral squamous cell...
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Current Trends in Steroid Chemistry
Literature data over the past 10 years on the search for new drugs based on synthetic steroids are summarized and reviewed. Modern achievements in...
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Synthesis and In Vitro Studies of O-Alkylaminoethylated Derivatives of 3E-Hydroximinocholestene as Potent and Selective Antileukemic Agents
New O -alkylaminoethylated derivatives of 3-hydroximinocholestene were synthesised and studied for in vitro cytotoxic effects. The obtained oily oxime...
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Synthesis, Characterization and Antimycobacterial Activity of Some Substituted Phenylpyridazinone Derivatives
Aseries 6-phenyl-2-(substituted methyl)-dihydropyridazinone derivatives ( 3a – 3f ) were synthesized using the interaction of 6-phenylpyridazinone with...
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Recent progress in biologically active indole hybrids: a mini review
The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological...
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BIOSYNTHESIS OF PLANT SUBSTANCES; BIOGENETIC RELATIONSHIPS
The bioactive substances in medicinal plants will be discussed on the basis of their chemical structure, or more precisely, of a...
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A Complex Approach to the Determination of Authenticity in the Development of Standard Samples for Ace Inhibitors
The continuous development of the pharmaceutical industry has accentuated the task of quality assurance of medicines, which can be solved using...
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Current Advancements for New Drug Discovery Against Dengue Virus: A Review (2015 – 2020)
Dengue fever is a viral ailment mostly found in tropical and sub-tropical communities. Dengue fever is spread by the mosquito Aedes aegypti....
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Search for Selective Glua1 Ampa Receptor Antagonists in a Series of Dicationic Compounds
Homologous series of dicationic derivatives based on adamantyl and phenylcyclohexyl fragments in which the cationic groups and the distance between...
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Determination of Three Gliptins in Tablets by Reversed Phase Liquid Chromatography with an Application of Spiked Urine Samples
A fast and reliable reversed-phase high-performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of...
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Dication Molecules as Tools for Studying Actylcholine and Glutamate Receptors (Review)
The review covers the pharmacochemical study of two receptor types, the neuronal nicotinate receptor and the glutamate receptor. The...
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Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity
BackgroundA variety of spirooxindoles have demonstrated cytotoxic activity toward several cancer cell lines. This study investigates the cytotoxicity...
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Development and Validation of a Stability-Indicating Related Substances RP-HPLC Method for Anagliptin and its Degradation Products
There is no stability-indicating specific related substances high-performance liquid chromatography (HPLC) method for anagliptin active...
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Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review
Among a large number of nitrogen-containing heterocyclic compounds, pyrazole is a privileged scaffold with the molecular formula C 3 H 3 N 2 H. It consists...
