The acute toxicity and analgesic activity of six compounds of the 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-one series were studied. The studied compounds had low toxicity and exhibited analgesic activity. Manifestation of the analgesic effect was associated with a thiophene ring and a 2-hydroxyethyl radical in the structures of the compounds.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 12, pp. 35 – 37, December, 2022.
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Gein, O.N., Rubtsova, D.D. & Gein, V.L. Acute Toxicity and Analgesic Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones. Pharm Chem J 56, 1604–1606 (2023). https://doi.org/10.1007/s11094-023-02833-0
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DOI: https://doi.org/10.1007/s11094-023-02833-0