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CU(II) Complex with Nicotine and Carcinogenicity of Raw Medical Tobacco

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Pharmaceutical Chemistry Journal Aims and scope

Unusual coordination of Cu(II) with the pyrrolidine N atom of nicotine in aqueous solution that could promote the formation of carcinogenic N-nitrosonornicotine in raw medical tobacco was shown using circular dichroism.

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References

  1. Voges Tobacco Encyclopedia. Tobacco Journal International, Verlags gruppe Rhein Main GmbH & Co KG, Mainz, Germany (2000).

  2. A. E. Osborn and V. Lanzoni, Plant-derived Natural Products. Synthesis, Function and Application, Springer, Dordrecht-Heidelberg-London-New York (2009).

  3. D. M. Obol′skii, T. A. Sokol′skaya, V. V. Vandyshev, and A. A. Denisov, Vopr. Biol., Med. Farm. Khim., 6(6), 15 – 18 (2008).

  4. D. G. Zaridze and R. Peto (eds.), Smoking and Health [in Russian], Meditsina, Moscow (1989), pp. 168 – 191.

  5. W. Caldwell, J. M. Green, D. R. Plowchalk, et al., Chem. Res. Toxicol., 4(5), 513 – 516 (1991).

    Article  CAS  Google Scholar 

  6. B. Cai, H. Ji, F. F. Fannin, et al., J. Nat. Prod., 79(4), 754 – 759 (2016).

    Article  CAS  Google Scholar 

  7. G. B. Neurath, M. Dunger, and F. G. Pein, IARC Sci. Publ., 14, 227 – 236 (1976).

    CAS  Google Scholar 

  8. N. N. Mel′nikov, Pesticides – Chemistry, Technology and Application [in Russian], Khimiya, Moscow (1987), pp. 668 – 670.

  9. S. Haque and S. J. P. Canete, 71st Tobacco Science Research Conference, Bonita Bay, USA, Abstr. 117 (2017).

  10. S. A. Haque and S. J. P. Canete, Ind. Crops Prod., 122, 493 – 497 (2018).

    Article  CAS  Google Scholar 

  11. B. Cai, B. Siminszky, J. Chappel, et al., J. Biol. Chem., 287(51), 42804 – 42811 (2012).

    Article  CAS  Google Scholar 

  12. B. Sun, Sh.-L. Xue, F. Zhang, et al., Int. J. Mol. Sci., 16(11), 27422 – 27432 (2015).

    Article  CAS  Google Scholar 

  13. G. Volpi, World J. Chem. Educ., 4(3), 67 – 72 (2016).

    CAS  Google Scholar 

  14. R. J. Robins, R. Molinie, R. A. Kwiecien, et al., Phytochem. Rev., 6, 51 – 63 (2007).

    Article  CAS  Google Scholar 

  15. S. E. Burkat, Zh. Obshch. Khim., 23, 1401 – 1405 (1953).

    CAS  Google Scholar 

  16. C. Smith, J. Am. Chem. Soc., 75, 2010 – 2012 (1953).

    Article  CAS  Google Scholar 

  17. A. F. Fazary, Chem. Sin., 8(4), 413 – 420 (2017); www.pelagiaresearchlibrary.com.

  18. A. Tomita, Ei-I. Ochiai, H. Hirai, et al., J. Inorg. Nucl. Chem., 29, 105 – 112 (1967).

  19. B. Jasiewicz, M. Hoffmann, A. Gasowska, et al., Acta Chim. Slov., 61, 137 – 144 (2014).

    CAS  PubMed  Google Scholar 

  20. C. Hirtenlehne and U. Monkowius, Inorg. Chem. Commun., 15, 109 – 112 (2012).

    Article  Google Scholar 

  21. Zh. Jiang, G. Tang, and L. Lu, Acta Crystallogr., Sect. E: Struct. Rep. Online, 64, m958-m959 (2008).

  22. C. Manfredi, S. Vero, E. Vasca, et al., J. Solution Chem., 45, 971 – 989 (2016).

    Article  CAS  Google Scholar 

  23. G. Snatzke (ed.), Optical Rotary Dispersion and Circular Dichroism in Organic Chemistry [Russian translation], Mir, Moscow (1970), pp. 9 – 21.

  24. P. M. Clayton, C. A. Vas, T. T. Bui, et al., Chirality, 25, 288 – 293 (2013).

    Article  CAS  Google Scholar 

  25. N. D. Grozdanic, M. S. Calado, M. L. J. Kievcanin, et al., J. Serb. Chem. Soc., 79(7), 829 – 842 (2014).

    Article  CAS  Google Scholar 

  26. V. A. Larionov, L. V. Yashkina, A. F. Smolyakov, et al., Chem. Select, 3, 653 – 656 (2018).

    CAS  Google Scholar 

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova St., Moscow, 119991, Russia

    K. K. Babievskii, A. B. Uryupin & K. A. Kochetkov

  2. D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    K. A. Kochetkov

Authors
  1. K. K. Babievskii
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  2. A. B. Uryupin
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  3. K. A. Kochetkov
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Corresponding author

Correspondence to A. B. Uryupin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 60 – 64, December, 2020.

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Babievskii, K.K., Uryupin, A.B. & Kochetkov, K.A. CU(II) Complex with Nicotine and Carcinogenicity of Raw Medical Tobacco. Pharm Chem J 54, 1290–1294 (2021). https://doi.org/10.1007/s11094-021-02358-4

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  • DOI: https://doi.org/10.1007/s11094-021-02358-4

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