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Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor
BackgroundThe human dopamine D2 receptor gene has three polymorphic variants that alter its amino acid sequence: alanine substitution by valine in...
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Acute behavioral effects of co-administration of mephedrone and MDMA in mice
BackgroundAbuse of more than one psychoactive drug is becoming a global problem. Our experiments were designed to examine the effects of a...
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The influence of electrical stimulation on dorsal raphe nucleus with different current intensities on morphine-induced conditioned place preference in male rats
IntroductionThe dorsal raphe nucleus (DRN) influences a wide range of behavioral and physiological processes. The purpose of the present study was to...
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Vortioxetine: A review of the pharmacology and clinical profile of the novel antidepressant
The aim of this paper was to review the up-to-date evidence base on pharmacology and clinical properties of vortioxetine.
Vortioxetine is a novel...
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Working memory deficits and alterations of ERK and CREB phosphorylation following withdrawal from cocaine self-administration
BackgroundThe mechanisms underlying memory functions during withdrawal from the chronic drug use are poorly understood.
MethodsWe assessed learning...
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Characterization of temporal expressions of FOXO and pFOXO proteins in the hippocampus by kainic acid in mice: involvement of NMDA and non-NMDA receptors
In the present study, we characterized the expression and role of forkhead box O (FoxO3a) in kainic acid (KA)-induced hippocampal neuronal cell...
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Opioid-induced redistribution of 6TM and 7TM μ opioid receptors: A hypothesized mechanistic facilitator model of opioid-induced hyperalgesia
Opioids are still the most popular form of pain treatment, but many unavoidable side effects make opioids a big challenge in effective pain...
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Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington’s like symptoms in rats: Possible neurotransmitters modulation
BackgroundHuntington Disease is autosomal, fatal and progressive neurodegenerative disorder for which clinically available drugs offer only...
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The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect
Depression is a serious global illness, becoming more and more common in developed countries. Because of specific symptoms it is considered as a...
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Effect of extended olanzapine administration on POMC and neuropeptide Y mRNA levels in the male rat amygdala and hippocampus
BackgroundNeuropeptides play an important role in various neural pathways, being able to control a wide spectrum of physiological responses....
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Succinate Receptors (SUCNR1) as a Potential Target for Pharmacotherapy
A considerable number of reports have been published in recent years on G protein-coupled receptors, their distribution in the body, mechanism of...
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The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect
Depression is one of the most common mental disorders and social issue worldwide. Although there are many antidepressants available, the...
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The influence of aripiprazole and olanzapine on the anxiolytic-like effect observed in prenatally stressed rats (animal model of schizophrenia) exposed to the ethyl alcohol
BackgroundSchizophrenia is a common disease which affect about 1% of global population. In that point of view animal model of schizophrenia seem to...
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Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs
The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of...
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Locomotor stimulation by acute propofol administration in rats: Role of the nitrergic system
BackgroundThe addictive potential of propofol has been scientifically discussed. Drugs’ psychostimulant properties that can be assessed via ...
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The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain
According to a current hypothesis of learning processes, recent papers pointed out to an important role of the extracellular signal-regulated kinase...
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Glutamate and modeling of schizophrenia symptoms: Review of our Findings: 1990–2014
In the early 90s, we studied the role of perception disturbances in schizophrenia in our first clinical approaches, using the Bender test in...
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Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi
BackgroundThe effect of the agonism on γ-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and...
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Context-controlled nicotine-induced changes in the labeling of serotonin (5-HT)2A and 5-HT2C receptors in the rat brain
BackgroundWe have previously demonstrated that serotonin (5-HT) 2A and 5-HT 2C receptor ligands modulate the sensitizing effects of nicotine. In the...
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Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism
The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent...