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Effects of a Long-Acting Diquafosol Ophthalmic Solution on the Ocular Surface, Tolerability, and Usability in Dry Eye Disease
IntroductionThis study aimed to investigate the tolerability of high-viscosity diquafosol tetrasodium (DQS) ophthalmic solution (DIQUAS LX; DQSLX)...
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Tolerability of Antihypertensive Medications: The Influence of Age
IntroductionDespite high prevalence of hypertension, few studies have analysed the adverse effects (AEs) of antihypertensive medications, especially...
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral AL01211 in Healthy Chinese Volunteers
Background and ObjectiveAberrant accumulation of glycosphingolipids (GSLs) in the lysosome leads to GSL storage diseases. Glucosylceramide synthase...
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Long-Term Efficacy and Tolerability of PCSK9 Targeted Therapy: A Review of the Literature
Increased plasma levels of low-density lipoprotein cholesterol (LDL-C) are causally associated with atherosclerotic cardiovascular disease (ASCVD),...
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Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study
IntroductionThe introduction of clacitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) has revolutionized the treatment of migraines. In...
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Design of mobile and website health application devices for drug tolerability in hereditary fructose intolerance
BackgroundHereditary fructose intolerance (HFI) is a rare metabolic disease caused by aldolase B deficiency. The aim of our study was to analyse...
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Mesenchymal Stem Cell Therapy in Acute Intracerebral Hemorrhage: A Dose-Escalation Safety and Tolerability Trial
BackgroundWe conducted a preliminary phase I, dose-escalating, safety, and tolerability trial in the population of patients with acute intracerebral...
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Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers
Background and ObjectiveDeficiencies of enzymes acting downstream of glucosylceramide synthase (GCS) can cause severe substrate accumulation....
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Assessing the safety and tolerability of rhinologic surgery under local anesthetic: an 8-year retrospective analysis
PurposeOffice-based rhinologic procedures (OBRP) have become widely available in North America due to technological advances and appropriate patient...
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Efficacy and Tolerability of Intranasal Midazolam Administration for Antiseizure Treatment in Adults: A Systematic Review
ObjectiveThe objective of this study was to assess the efficacy and tolerability of intranasal midazolam (in-MDZ) administration for antiseizure...
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Stapokibart in Healthy Volunteers and Adult Subjects with Atopic Dermatitis
IntroductionStapokibart, a novel humanized anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits the signaling of IL-4 and IL-13,...
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Safety and tolerability of Sacubitril/Valsartan in heart failure patient with reduced ejection fraction
BackgroundAngiotensin receptor blocker and a neprilysin inhibitor (ARNI) has emerged as an innovative therapy for patients of heart failure with...
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Tolerability and effectiveness of palbociclib in older women with metastatic breast cancer
PurposePalbociclib has become the standard of care for estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-)...
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An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)
BackgroundGlobally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative...
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The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
IntroductionIn vitro and pre-marketing clinical data have shown the healing properties of a postbiotic extract from Aquaphilus dolomiae (ADE-G2)....
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Safety, Tolerability and Pharmacokinetics of Single-Dose Oral SYHA1402 in Healthy Chinese Subjects
IntroductionTo assess the safety, tolerability and pharmacokinetics of a single dose of SYHA1402 in healthy Chinese subjects.
Methods ...
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Efficacy and tolerability of the Subcutaneous Semaglutide for type 2 Diabetes patients: an updated systematic review and meta-analysis
ObjectivesTo update and assess the efficacy and tolerability of once weekly subcutaneous semaglutide in patients with type 2 diabetes (T2D).
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How do patients interpret and respond to a single-item global indicator of cancer treatment tolerability?
BackgroundThere is increasing interest in patient-reported measures of cancer treatment tolerability. A global measure of bother, the FACT GP5 item...
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Safety, Tolerability, and Outcomes of Tafamidis for the Treatment of Acquired Amyloid Neuropathy in Domino Liver Transplant Recipients
IntroductionAcquired amyloid neuropathy is an iatrogenic disease that appears years after a domino liver transplant. The objectives of our study are...
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SAFE-ROCK: A Phase I Trial of an Oral Application of the ROCK Inhibitor Fasudil to Assess Bioavailability, Safety, and Tolerability in Healthy Participants
BackgroundThe intravenous (IV) formulation of Rho-kinase (ROCK) inhibitor fasudil has been approved for the treatment of subarachnoid haemorrhage...
