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Assessing the Long-Term (48-Week) Effectiveness, Safety, and Tolerability of Fremanezumab in Migraine in Real Life: Insights from the Multicenter, Prospective, FRIEND3 Study
IntroductionLong-term (1-year) fremanezumab treatment proved to be effective, safe, and well tolerated in individuals with migraine and < 2...
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Long-term safety and tolerability of ambrisentan treatment for pediatric patients with pulmonary arterial hypertension: An open-label extension study
This open-label, extension study assessed long-term safety, tolerability, and efficacy of ambrisentan in a pediatric population (age 8– < 18 years)...
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Efficacy, safety, and tolerability of antimicrobial agents for complicated intra-abdominal infection: a systematic review and network meta-analysis
BackgroundWhich antimicrobial agents provide the optimal efficacy, safety, and tolerability for the empirical treatment of complicated...
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Efficacy, feasibility and tolerability of ketogenic diet for the treatment of poor response to bariatric surgery
PurposePoor response to bariatric surgery, namely insufficient weight loss (IWL) or weight regain (WR), is a critical issue in the treatment of...
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Safety and tolerability of atogepant for the preventive treatment of migraine: a post hoc analysis of pooled data from four clinical trials
BackgroundConventional, non-specific preventive migraine treatments often demonstrate low rates of treatment persistence due to poor efficacy or...
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Effectiveness and tolerability of camrelizumab combined with molecular targeted therapy for patients with unresectable or advanced HCC
There is a lack of effective programmed cell death protein 1 (PD-1)‐targeted immunotherapy with good tolerability in patients with advanced...
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Safety, Tolerability, Bioavailability, and Biological Activity of Inhaled Interferon-α2b in Healthy Adults: The IN2COVID Phase I Randomized Trial
Background and ObjectivesInterferons have been identified as a potential treatment alternative for coronavirus disease 2019. This study assessed the...
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Satisfaction and tolerability using virtual reality (VR) as adjunctive treatment during flexible bronchoscopy: a randomized control trial
BackgroundPatient comfort during invasive and therapeutic procedures is important. The use of virtual reality (VR) devices during flexible...
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Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s: a study protocol
BackgroundParkinson’s disease (PD) is the fastest growing neurological condition worldwide. Recent theories suggest that symptoms of PD may arise due...
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Safety, Tolerability, and Pharmacokinetics of Oral BI 1358894 in Healthy Japanese Male Volunteers
Background and ObjectivesBI 1358894, a novel small-molecule inhibitor of transient receptor potential canonical ion channels, is under development...
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A randomized controlled double-blinded split-face prospective clinical trial to assess the efficacy, safety, and tolerability of a novel 3-step routine compared to benzoyl peroxide for the treatment of mild to moderate acne vulgaris
Adult acne vulgaris affects up to 43–51% of individuals. While there are numerous treatment options for acne including topical, oral, and...
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The utility and tolerability of ultrasound guided muscle biopsy in the investigation of myopathy: a follow-up study
IntroductionOpen surgical muscle biopsy has traditionally been required for the histological diagnosis of myopathy but requires neurosurgical...
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Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study
BackgroundAD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing...
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Safety and Tolerability of Antimicrobial Agents in the Older Patient
Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial...
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First-in-Human Safety, Tolerability, and Pharmacokinetics of Single-Dose Kukoamine B Mesylate in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase I Study
IntroductionKukoamine B mesylate (KB) is a mesylate chrysamine B targeting lipopolysaccharides and CpG DNA, two potential treatment targets in sepsis.
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Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study
BackgroundDolutegravir is an integrase strand transfer inhibitor that has been recommended for use in first-line antiretroviral regimens by the World...
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Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
BackgroundWe compared the efficacy, tolerability, and safety of oral sulfate tablets (OST, which contains simethicone) and 2 L-polyethylene...
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Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
BackgroundGalcanezumab has shown efficacy and effectiveness in the treatment of episodic and chronic migraine (CM), however, the population...
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Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies
Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom...
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Comparing the tolerability of preservative-free tafluprost versus preserved latanoprost in the management of glaucoma and ocular hypertension — an observer blinded active-control trial
BackgroundDry eye is a condition related to long-term topical eye therapy. We wish to evaluate the effectiveness and tolerability of preservative...
