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Desmin Degradation in Skeletal Muscles of Patients with Chronic Critical Illness
AbstractPatients with chronic critical illness lose a considerable portion of their muscle mass while hospitalized in an intensive care unit, which...
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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders
Lysosomal storage disorders (LSDs), which are characterized by genetic and metabolic lysosomal dysfunctions, constitute over 60 degenerative diseases...
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The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling
Locomotor activity is an innate behavior that can be triggered by gut-motivated conditions, such as appetite and metabolic condition. Various...
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Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains?
The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under...
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Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model
Spinal muscular atrophy (SMA) is a genetic disease resulting in the loss of α-motoneurons followed by muscle atrophy. It is caused by knock-out...
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Pedal Morphology and Locomotor Behavior of the Subfossil Lemurs of Madagascar
The subfossil lemurs of Madagascar have been discussed and studied in great detail due to their remarkable preservation, phylogenetic history, and...
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Central and Peripheral Fatigue
Skeletal muscle fatigue, characterized by a temporary decline in the ability to generate force or power output, encompasses peripheral and central...
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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury
BackgroundLimited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital...
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Analyses of the pericyte transcriptome in ischemic skeletal muscles
BackgroundPeripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the...
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Quantification of Muscle Stem Cell Differentiation Using Live-Cell Imaging and Eccentricity Measures
Culturing primary muscle stem cellsMuscle stem cells ex vivo is a useful method for studying this cell population in controlled environments. Primary...
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Evolution of Hominids
Among the primates, one group stands out by a huge brain, short dental arcade without prominent canines, habitually upright body posture, absence of...
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Primate Foot Use During Bipedal Walking
The foot is the body’s sole point of contact with the substrate during bipedal walking, making it key to understanding the evolution of bipedality in...
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Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury
Macrophage/microglia polarization acts as an important part in regulating inflammatory responses in spinal cord injury (SCI). However, the regulation...
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The Role of Histone Deacetylases I and IIa (HDAC1, HDAC4/5) and the MAPK38 Signaling Pathway in the Regulation of Atrophic Processes under Skeletal Muscle Unloading
AbstractVarious forms of muscle unloading can be found in patients with prolonged bed rest, with strokes and spinal lesions, during muscle...
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Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle
BackgroundDuchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current...
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The emerging role of Piezo1 channels in skeletal muscle physiology
Piezo1 channels are mechanically activated (MA) cation channels that are involved in sensing of various mechanical perturbations, such as membrane...
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Protective effect of bone morphogenetic protein-7 induced differentiation of bone marrow mesenchymal stem cells in rat with acute spinal cord injury
The principal aim of present study was to assess the therapeutic efficacy of bone morphogenetic protein-7 (BMP-7) induced differentiation of bone...
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Circadian Control of Transcriptional and Metabolic Rhythms in Primary Hepatocytes
Isolation of primary hepatocytes and culturing these cells ex vivo provides a powerful platform to model liver physiology in vivo. Primary...
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State of the Art Procedures for the Isolation and Characterization of Mesoangioblasts
Adult skeletal muscle is a dynamic tissue able to regenerate quite efficiently, thanks to the presence of stem cell machinery. Besides the quiescent...
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What Have the Extremities of “Lower Tetrapods” in Common? And Why?
Most primitive tetrapods possess a rather slender trunk, neck of short or medium length and a long tail (see Chap. 4...