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Multivariate Optimization and Validation of HPLC Method for Determination of Spiramycin I in Tablets
Spiramycin (SPY) is an antibiotic belonging to the class of macrolides. Its main structurally related components are SPY I, SPY II and SPY III. The...
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On-line Method for Montelukast Determination in Bile Salt Medium with Multivariate Optimization and Fluorescent Detection
AbstractThe present development involved a flow injection strategy using a mini-column of multiwalled carbon nanotubes and fluorescent detection (λ ex ...
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Multivariate optimization of a green procedure for determination of emerging polycyclic aromatic nitrogen heterocycles in PM2.5 from sites with different characteristics
Emerging polycyclic aromatic nitrogen heterocycles (PANHs) contributes significantly to the health risk associated with inhaling polluted air....
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A case study: Correlation of the nutrient composition in Chinese Hamster Ovary cultures with cell growth, antibody titre and quality attributes using multivariate analyses for guiding medium and feed optimization in early upstream process development
In this case-study, we demonstrate an approach for identifying correlations between nutrients/metabolites in the spent medium of CHO cell cultures...
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Multivariate Optimization of Operational Parameters in Microfluidic Paper-Based Analytical Devices for the Determination of Organophosphate and Carbamate Pesticides
AbstractThe aim of this study is to employ a response surface methodology (RSM) to optimize experimental parameters in microfluidic paper-based...
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Organic/inorganic nanohybrid of MgAl@CuFe2O4-polylysine for hazardous Cr(VI) and methyl orange uptake: Multivariate optimization and isotherm study
An efficient organic/inorganic magnetic nanohybrid of MgAl@CuFe 2 O 4 -polylysine was successfully synthesized and employed as a suitable adsorbent for...
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Multivariate Analysis as Tool for Optimization of Anthocyanins Extraction from Jambolan (Syzygium cumini L.)
Jambolan is a fruit characterized by its high content of bioactive compounds, especially anthocyanins. The present study aimed to optimize the...
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Label-free SERS assay combined with multivariate spectral data analysis for lamotrigine quantification in human serum
Considering the need for a more time and cost-effective method for lamotrigine (LTG) detection in clinics we developed a fast and robust label-free...
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Multivariate optimization of a method based on slurry sampling for determination of Fe, Mn and Zn in spirulina (Arthrospira sp.) samples
In the present work a novel methodology for the determination of Fe, Mn, and Zn by flame atomic absorption spectrometry in samples of spirulina,...
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Multivariate Sonication-Based Extraction Optimization to Improve the Antioxidant and Anti-Inflammatory Properties of Anacyclus pyrethrum var. Pyrethrum Root Extracts
The roots of the medicinal plant Anacyclus pyrethrum have been acknowledged for their therapeutic potential in both conventional and contemporary...
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Multivariate investigation of physicochemical, nutritional and sensory attributes of traditional Lebanese grape molasses
Grape molasses is a natural sweetener widely consumed in Lebanon and Eastern Mediterranean countries. However, the lack of national standards that...
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Univariate versus multivariate spectrophotometric data analysis of triamterene and xipamide; a quantitative and qualitative greenly profiled comparative study
Triamterene (TRI) and xipamide (XIP) mixture is used as a binary medication of antihypertension which is considered as a major cause of premature...
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QbD/PAT—State of the Art of Multivariate Methodologies in Food and Food-Related Biotech Industries
Several investigations have been made at lab scale considering the quality by design (QbD) and process analytical technology (PAT) approaches....
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Modeling and optimization of the prediction of bio-oil yield using generalized approach with different biomass and reactor types
Fourteen multivariate regression models were applied to model the bio-oil yield obtained by pyrolysis using different combinations of predictor...
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Determining the Total Content of Similar Substances Using Integrated Indices or Multivariate Calibrations at a High Intragroup Selectivity of Signals
AbstractThe total content c Σ of similar organic compounds is conventionally determined without their separation by measuring their generalized...
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Hyperspectral Imaging Coupled with Multivariate Analyses for Efficient Prediction of Chemical, Biological and Physical Properties of Seafood Products
Quality evaluation of seafood is essential for consumer satisfaction. Hyperspectral imaging (HSI) has been introduced in the seafood industry for...
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A multivariate optimization of bioactive compounds extracted from oregano (Origanum vulgare) leaves using pulsed mode sonication
In this study, pulsed mode ultrasound assisted extraction (PUAE) was investigated as green technology for the extraction of bioactive compounds from...
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Multivariate optimization of an ultrasound-assisted extraction method of bioactive phenolic compounds in malagueta peppers (Capsicum frutescens)
The use of statistical tools in the optimization of bioactive extraction processes increases efficiency and reduces process costs, indicating the...
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Evaluation of NMR-based strategies to differentiate fresh from frozen-thawed fish supported by multivariate data analysis
The differentiation of fresh and frozen-thawed fish is a relevant authenticity aspect as in the European Union fish holds a high statistical risk of...
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Osmo-air drying of banana slices: multivariate analysis, process optimization and product quality characterization
In the present work, osmotic dehydration (OD) was applied as a pretreatment to hot air drying of banana slices and the effect of OD parameters on...
