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Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems
Liquid chromatography/mass spectrometry (LC/MS) has become a routine powerful technology in clinical proteomic studies for protein identification,...
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Quantification of Mycophenolic Acid in Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Mycophenolate mofetil (MMF) and sodium mycophenolate are commonly prescribed immunosuppressive drugs for patients who have undergone solid organ...
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Mass Spectrometry with High-Performance Liquid Chromatography
Mass spectrometry (MS) is an analytical technique that provides information about the molecular weight and chemical characteristics of a compound....
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Quantification of Olanzapine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Olanzapine (Zyprexa™) is indicated for the treatment of schizophrenia and bipolar disorder. Olanzapine is metabolized to inactive metabolites;...
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Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole
Antifungal therapy with triazole drugs including posaconazole, voriconazole, itraconazole, and its active metabolite hydroxyitraconazole is routinely...
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Development of Liquid Chromatography-Mass Spectrometry (LC-MS) Method for Quantification of Broccoli Sulforaphane
Sulforaphane (SFN) is an isothiocyanate and the product of the hydrolysis of glucoraphanin (GRA) by myrosinase. Broccoli is one of the rich sources...
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Quantification of Oxcarbazepine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Oxcarbazepine (Trileptal®) has been found effective in the treatment of tonic-clonic seizures and partial seizures with or without secondary...
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Metabolomics Analysis of Aqueous Humor Based on Liquid Chromatography–Mass Spectrometry
Aqueous humor (AH) is a transparent fluid that fills the anterior segment of the eye. The composition and level of metabolites in AH are important...
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Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
The thiopurine drugs, azathioprine, mercaptopurine, and thioguanine, are widely used in the treatment of several malignant and nonmalignant diseases....
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Quantitative Opiate, Opioid, and Benzodiazepine Testing by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Fatalities due to opioids and other controlled substances continue to increase year over year and maintain an epidemic level nationally. CDC data...
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Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital
Pentobarbital is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties. Pentobarbital may be used to induce sedation,...
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System Performance Monitoring in Clinical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Quality assurance (QA) activities enable continuous improvement through ongoing post-implementation monitoring to identify, evaluate, and correct...
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Simultaneous quantification of ferrous gluconate and calcium gluconate in foods using liquid chromatography–tandem mass spectrometry (LC–MS/MS)
Ferrous gluconate and calcium gluconate are used as food acidity regulators in South Korea, Japan, the European Union (EU), and other countries. A...
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Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Nicotine is a naturally occurring and highly addictive chemical used in e-cigarettes, cigarettes, chewing tobacco, and other tobacco products as well...
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Determination of Thiopurine S-Methyltransferase (TPMT) Activity in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Thiopurine methyltransferase (TPMT) is a cytosolic enzyme involved in the metabolism of thiopurine medications that are used in the treatment of...
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Quantification of Amino Acids in Plasma by High-Performance Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS)
For the extraction and measurement of plasma amino acids using LC/ESI–MS/MS technology, a straightforward and dependable approach has been...
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Screening of Antimicrobial Residues in Muscle fromDifferent Species by Liquid Chromatography Coupled with Tandem Mass Spectrometry
A screening methodology for the analysis of 46 antimicrobial (ATB) residues has been developed and validated for application in muscle samples...
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Screening of Contaminants of Emerging Concern (CECs) in Fish and Milk Samples by Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS)
Contaminants of emerging concern (CECs) have been the main focus of food toxicology and environmental chemistry in recent years due to their extended...
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Quantitation of Aldosterone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Accurate determination of serum and plasma aldosterone is essential for screening, diagnosis, and subtype classification of primary aldosteronism...
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Analysis of Barbiturates in Urine by LC-MS/MS
In the method described here, an aliquot of a urine sample is analyzed to detect barbiturates through dilution and ultra-high-performance...