Abstract
Contaminants of emerging concern (CECs) have been the main focus of food toxicology and environmental chemistry in recent years due to their extended usage, continued emission, and potential ecotoxicological effects. CECs are ubiquitous in the environment and can be bioaccumulated and biomagnified in aquatic and terrestrial organisms that might be eventually consumed by humans. Here we describe analytical methods for the analysis of CECs in fish muscle, commercial milk (i.e., liquid and powder), and human breast milk samples by means of liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-HRMS/MS).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Chiaia-Hernandez AC, Krauss M, Hollender J (2013) Screening of lake sediments for emerging contaminants by liquid chromatography atmospheric pressure photoionization and electrospray ionization coupled to high resolution mass spectrometry. Environ Sci Technol 47:976–986. https://doi.org/10.1021/es303888v
Dulio V, van Bavel B, Brorström-Lundén E et al (2018) Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations. Environ Sci Eur 30:5. https://doi.org/10.1186/s12302-018-0135-3
Escher BI, Stapleton HM, Schymanski EL (2020) Tracking complex mixtures of chemicals in our changing environment. Science 367:388–392. https://doi.org/10.1126/science.aay6636
Tkalec Ž, Codling G, Tratnik JS et al (2022) Suspect and non-targeted screening-based human biomonitoring identified 74 biomarkers of exposure in urine of Slovenian children. Environ Pollut 313:120091. https://doi.org/10.1016/j.envpol.2022.120091
Dennis KK, Jones DP (2016) The exposome: a new frontier for education. Am Biol Teach 78:542–548. https://doi.org/10.1525/abt.2016.78.7.542
Yusa V, Millet M, Coscolla C, Roca M (2015) Analytical methods for human biomonitoring of pesticides. A review. Anal Chim Acta 891:15–31. https://doi.org/10.1016/j.aca.2015.05.032
Siddique S, Kubwabo C, Harris SA (2016) A review of the role of emerging environmental contaminants in the development of breast cancer in women. Emerg Contam 2:204–219. https://doi.org/10.1016/j.emcon.2016.12.003
Jadhav MR, Pudale A, Raut P et al (2019) A unified approach for high-throughput quantitative analysis of the residues of multi-class veterinary drugs and pesticides in bovine milk using LC-MS/MS and GC–MS/MS. Food Chem 272:292–305. https://doi.org/10.1016/j.foodchem.2018.08.033
Zheng G, Han C, Liu Y et al (2014) Multiresidue analysis of 30 organochlorine pesticides in milk and milk powder by gel permeation chromatography-solid phase extraction-gas chromatography-tandem mass spectrometry. J Dairy Sci 97:6016–6026. https://doi.org/10.3168/jds.2014-8192
Beyene T (2015) Veterinary drug residues in food-animal products: its risk factors and potential effects on public health. J Veterinar Sci Technol 07. https://doi.org/10.4172/2157-7579.1000285
Lopez-Herguedas N, González-Gaya B, Castelblanco-Boyacá N et al (2022) Characterization of the contamination fingerprint of wastewater treatment plant effluents in the Henares River Basin (central Spain) based on target and suspect screening analysis. Sci Total Environ 806:151262. https://doi.org/10.1016/j.scitotenv.2021.151262
Mijangos L, Ziarrusta H, Zabaleta I et al (2019) Multiresidue analytical method for the determination of 41 multiclass organic pollutants in mussel and fish tissues and biofluids by liquid chromatography coupled to tandem mass spectrometry. Anal Bioanal Chem 411:493–506
Justino CIL, Duarte KR, Freitas AC et al (2016) Contaminants in aquaculture: overview of analytical techniques for their determination. TrAC Trends Anal Chem 80:293–310. https://doi.org/10.1016/j.trac.2015.07.014
Ziarrusta H, Val N, Dominguez H et al (2017) Determination of fluoroquinolones in fish tissues, biological fluids, and environmental waters by liquid chromatography tandem mass spectrometry. Anal Bioanal Chem 409:6359–6370. https://doi.org/10.1007/s00216-017-0575-4
Zabaleta I, Bizkarguenaga E, Iparragirre A et al (2014) Focused ultrasound solid–liquid extraction for the determination of perfluorinated compounds in fish, vegetables and amended soil. J Chromatogr A 1331. https://doi.org/10.1016/j.chroma.2014.01.025
Baduel C, Mueller JF, Tsai H, Gomez Ramos MJ (2015) Development of sample extraction and clean-up strategies for target and non-target analysis of environmental contaminants in biological matrices. J Chromatogr A 1426:33–47. https://doi.org/10.1016/j.chroma.2015.11.040
Musatadi M, González-Gaya B, Irazola M et al (2020) Focused ultrasound-based extraction for target analysis and suspect screening of organic xenobiotics in fish muscle. Sci Total Environ 740:139894. https://doi.org/10.1016/j.scitotenv.2020.139894
Musatadi M, González-Gaya B, Irazola M et al (2021) Multi-target analysis and suspect screening of xenobiotics in milk by UHPLC-HRMS/MS. Separations 8:14. https://doi.org/10.3390/separations8020014
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
About this chapter
Cite this chapter
Musatadi, M., González-Gaya, B., Prieto, A., Olivares, M., Zuloaga, O. (2024). Screening of Contaminants of Emerging Concern (CECs) in Fish and Milk Samples by Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS). In: Hoff, R., Molognoni, L. (eds) Chemical Food Contaminants Analysis. Methods and Protocols in Food Science . Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3806-4_16
Download citation
DOI: https://doi.org/10.1007/978-1-0716-3806-4_16
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-3805-7
Online ISBN: 978-1-0716-3806-4
eBook Packages: Springer Protocols