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Detection of goat milk adulteration in horse milk using LC-HRMS-based non-targeted metabolomics and chemometrics
For economic reasons, high-price milk, such as horse milk (HM), can be adulterated using lower-price milk by unethical producers and traders. Milk...
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Determination of hair cortisol in horses: comparison of immunoassay vs LC-HRMS/MS
The measure of hair cortisol concentration (HCC) is becoming an emerging approach to monitor mid-/long-term stress in animals, so it is more and more...
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Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay
C-type lectin receptors (CLRs), which are pattern recognition receptors responsible for triggering innate immune responses, recognize damaged...
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Metabolomics and Proteomics Approach Using LC-Orbitrap HRMS for the Detection of Pork in Tuna Meat for Halal Authentication
Adulteration of high-quality meat with non-halal meats causes a serious problem for some religions such as Muslim and Jewish. Tuna meat (TM) can be...
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LC-ESI-HRMS — lipidomics of phospholipids
Lipids are a diverse class of molecules involved in many biological functions including cell signaling or cell membrane assembly. Owing to this...
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A green-footprint approach for parallel multiclass analysis of contaminants in roasted coffee via LC-HRMS
The development and validation of a simple, comprehensive, and environment-friendly procedure to determine pesticide residues, naturally occurring...
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LC-Orbitrap-HRMS method for analysis of traces of triacylglycerols featuring furan fatty acids
Furan fatty acids (FuFAs) are valuable antioxidants that are highly relevant for the protection of polyunsaturated fatty acids (PUFAs) in biological...
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Linking MS1 and MS2 signals in positive and negative modes of LC-HRMS in untargeted metabolomics using the ROIMCR approach
Data-independent acquisition (DIA) mode in liquid chromatography (LC) high-resolution mass spectrometry (HRMS) has emerged as a powerful strategy in...
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Screening of Contaminants of Emerging Concern (CECs) in Fish and Milk Samples by Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS)
Contaminants of emerging concern (CECs) have been the main focus of food toxicology and environmental chemistry in recent years due to their extended...
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Intact quantitative bioanalytical method development and fit-for-purpose validation of a monoclonal antibody and its related fab fragment in human vitreous and aqueous humor using LC-HRMS
Ranibizumab is an FDA-approved drug used to treat wet age-related macular degeneration (AMD), diabetic retinopathy, macular edema, and myopic...
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Differentiation of industrial hemp strains by their cannabinoid and phenolic compounds using LC × LC-HRMS
Cannabis is an ancient plant that has been used for therapeutic and recreational purposes. Nowadays, industrial hemp, a variety with low...
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HPLC–UV Monitored Photostability-Test of LE404 and Identification of the Degradation Products via NMR and LC–HRMS
Dibenzoazecines are a new class of potential neuroleptics with a high potential for the treatment of schizophrenia. Initial stress tests indicated...
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Dispersive magnetic solid-phase extraction for capsaicinoid compounds in human serum using LC-HRMS: targeted and non-targeted approaches
A new analytical method based on the use of dispersive magnetic solid-phase extraction (DMSPE) is described for the preconcentration of capsaicin...
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Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS—method development, validation, comparison of four sample matrices, and proof of concept
Oral endocrine therapies (OET) for breast cancer treatment need to be taken over a long period of time and are associated with considerable side...
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Comparison of chemometric strategies for potential exposure marker discovery and false-positive reduction in untargeted metabolomics: application to the serum analysis by LC-HRMS after intake of Vaccinium fruit supplements
Untargeted liquid chromatographic-high-resolution mass spectrometric (LC-HRMS) metabolomics for potential exposure marker (PEM) discovery in...
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A novel workflow for semi-quantification of emerging contaminants in environmental samples analyzed by LC-HRMS
There is an increasing need for develo** a strategy to quantify the newly identified substances in environmental samples, where there are not...
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LC-Q/TOF-HRMS and NMR Based Structural Characterization of the Major Photodegradation Impurity of Difluprednate
Difluprednate (DFL) is a corticosteroid used topically, especially in the form of emulsion for the treatment of inflammation and pain associated with...
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Closing the gap — development of an analytical methodology using volumetric absorptive microsampling of finger prick blood followed by LC-HRMS/MS for adherence monitoring of antihypertensive drugs
Volumetric absorptive microsampling (VAMS), an emerging microsampling technique, is a promising tool for adherence monitoring. This study focused on...
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LC-HRMS screening of per- and polyfluorinated alkyl substances (PFAS) in impregnated paper samples and contaminated soils
High per- and polyfluorinated alkyl substance (PFAS) concentrations have been detected in agricultural soils in Southwest Germany. Discharges of...
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Development and validation of an LC-HRMS method for the determination of pyrrolizidine alkaloids and quinolones in honey employing a simple alkaline sample dilution
Honey residue and contaminant assessments are extremely important, as they deal with food and therapeutic safety issues of a widely consumed animal...
