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Exploring the sequence-function space of microbial fucosidases
Microbial α- l- fucosidases catalyse the hydrolysis of terminal α- l -fucosidic linkages and can perform transglycosylation reactions. Based on sequence...
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Sicherheitsrelevante/unerwünschte Stoffe – Kontaminanten, Prozesskontaminanten und Rückstände
Aufgrund verschiedener Kontaminationsrisiken und durch ständig verfeinerte Analysentechniken mit extrem niedrigen Erfassungsgrenzen sowie nicht...
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CE-MS/MS and CE-timsTOF to separate and characterize intramolecular disulfide bridges of monoclonal antibody subunits and their application for the assessment of subunit reduction protocols
Characterization at the subunit level enables detailed mass spectrometric characterization of posttranslational modifications (PTMs) of monoclonal...
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Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows
Antibody-drug conjugates (ADCs) are highly complex proteins mainly due to the structural microvariability of the mAb, along with the additional...
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Strand displacement–triggered FRET nanoprobe tracking TK1 mRNA in living cells for ratiometric fluorimetry of nucleic acid biomarker
A precisely designed dual-color biosensor has realized a visual assessment of thymidine kinase 1 (TK1) mRNA in both living cells and cell lysates....
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Multi-omics characterization of NIST seafood reference materials and alternative matrix preparations
The National Institute of Standards and Technology (NIST) has prepared four seafood reference materials (RMs) for use in food safety and nutrition...
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Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins
PurposeThe leaky gut barrier is an important factor leading to various inflammatory gastrointestinal disorders. The nutritional value of honey and...
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Effects of the drying method and extraction solvent on antioxidant and anti-inflammatory activity of Melosira nummuloides bioproducts
Melosira nummuloides is a marine diatom with potential use as food, fuel, and a dietary supplement. However, the efficacy of its extraction and...
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Flow Dynamics and Analyte Transfer in a Microfluidic Device for Spatial Two-Dimensional Separations
In the last decade, chip-based separations have become a major area of interest in the field of separation science, especially for the development of...
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Determination of Ochratoxin A in Plant Products: Immunoaffinity Column and Liquid Chromatography with Fluorescence Detector
Ochratoxins are mycotoxins produced by various fungi of the genus Aspergillus and Penicillium, e.g., A. ochraceus, A. carbonarius, and P. verrucosum....
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Effect of drying methods on free and bound phenolic compounds, antioxidant capacities, and bioaccessibility of Cornelian cherry
Cornus mas L. (Cornelian cherry, CM) fruits were dehydrated by solar-drying (SD) and freeze-drying (FD), and in addition to sugar and mineral...
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Probing Antibody Structures by Hydrogen/Deuterium Exchange Mass Spectrometry
Hydrogen/deuterium exchange (HDX) followed by mass spectrometry detection (MS) provides a fast, reliable, and detailed solution for the assessment of...
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Bioanalysis of ursodeoxycholic acid and its metabolites and improved oral bioavailability using mixed micelles with poloxamer 407 and polysorbate 80
The development of analytical methods for endogenous therapeutic substances is a critical but challenging issue as obtaining a blank matrix without...
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Effects of different drying processes on the flavonoids characteristics of Guanxi honey pomelo (Citrus grandis (L.) Osbeck) peel by HPLC-Q-TOF-MS analysis
Citrus peels are rich in flavonoids, and some valuable flavonoids with health benefits, such as polymethoxyflavones (PMFs), are found almost...
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Interplay between photosynthetic electron flux and organic carbon sinks in sucrose-excreting Synechocystis sp. PCC 6803 revealed by omics approaches
BackgroundAdvancing the engineering of photosynthesis-based prokaryotic cell factories is important for sustainable chemical production and requires...
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Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system
Human carboxylesterase 2 (hCE2), one of the most principal drug-metabolizing enzymes, catalyzes the hydrolysis of a variety of endogenous esters,...
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Effect of different drying methods on the phenolic and volatile compounds of persimmon (Diospyros kaki L.)
Persimmon is a fruit much appreciated for its flavor and aroma, presenting high nutritional value and health-beneficial compounds. As it is a...
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The effects of different drying methods on the sugar, organic acid, volatile composition, and textural properties of black ‘Isabel’ grape
In this study, the black ‘Isabel’ grapes were dried by hot-air (HAD), vacuum (VD), ultrasound-assisted vacuum (US-VD), and freeze-drying (FD)...
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Co-pyrolysis of poly (methyl methacrylate) and sugarcane bagasse evaluated through multiple kinetic analysis methods
The aim of present work is to evaluate pyrolysis characteristics of poly(methyl methacrylate) (PMMA) and its blends with sugarcane bagasse (SB)...
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Atmospheric pressure field desorption-trapped ion mobility-mass spectrometry coupling
While field ionization (FI) and field desorption (FD) are established soft vacuum ionization methods in mass spectrometry (MS), the technique of...
