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Aptamer-based Membrane Protein Analysis and Molecular Diagnostics
Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities. Analysis of membrane proteins is...
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Research progress on the detection of foodborne pathogens based on aptamer recognition
Foodborne diseases caused by bacterial contamination are a serious threat to food safety and human health. The classical plate culture method has the...
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Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery
Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles...
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Low-cost, portable, on-site fluorescent detection of As(III) by a paper-based microfluidic device based on aptamer and smartphone imaging
A turn-on fluorescent aptasensor based on a paper-based microfluidic chip was developed to detect arsenite via aptamer competition strategy and...
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A Reagentless Aptamer Sensor Based on a Self-Powered DNA Machine for Electrochemical Detection of AFB1
Here, we developed a novel reagentless aptamer sensor for the detection of aflatoxin B1 (AFB1) that uses a DNA walker strategy and bisferrocene to...
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A Simple Aptamer-Based Nanoconjugate Assay for Diagnosis of Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) as a bone marrow stem cell clonal disease appears from the proliferation of granulocyte cells at all stages of...
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A colorimetric aptasensor for detecting ochratoxin A based on label-free aptamer and gold nanozyme
In this study, the aptamer of ochratoxin A (OTA) increased the negative charge density on the surface of gold nanoparticles (AuNPs) and promoted the...
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Aptamer-based CRISPR-Cas powered diagnostics of diverse biomarkers and small molecule targets
CRISPR-Cas systems have been widely used in genome editing and transcriptional regulation. Recently, CRISPR-Cas effectors are adopted for biosensor...
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Aptamer-Based Targeted Drug Delivery Systems
Nano-therapeutics often aims to design site-specific delivery of the therapeutics at the molecular level to treat diseased tissues or organs. On the...
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Aptamer-based protein molecule detection via cyclic reverse transcription coupling with self-priming hairpin-triggered CRISPR-Cas12a system
Protein biomarkers (e.g . thrombin) are of great significance for the biological process of the organism, and its aberrant expression is closely...
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A highly sensitive strategy for glypican-3 detection based on aptamer/gold carbon dots/magnetic graphene oxide nanosheets as fluorescent biosensor
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in China. Glypican-3 (GPC3) is a specific antigen related to HCC,...
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Dual-mode colorimetric electrochemical aptamer sensor based on Au@Pd bimetallic nanoparticles for the detection of Pb(II) in edible mushrooms
Pb(II) can accumulate in the body and gradually cause irreversible harm. In this work, a dual-mode colorimetric biosensor based on an aptamer was...
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Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors
Highly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases....
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Rapid and sensitive determination of histamine based on a fluorescent aptamer probe with analogue on carbonized polymer dots
Histamine (HA) plays an important role in many pathological processes including asthma, diarrhea, and anaphylactic shock. Therefore, accurate and...
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A signal “on–off-on”-type electrochemiluminescence aptamer sensor for detection of sulfadimethoxine based on Ru@Zn-oxalate MOF composites
An “on–off-on”-type electrochemiluminescence (ECL) aptamer sensor based on Ru@Zn-oxalate metal–organic framework (MOF) composites is constructed for...
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FFF-based high-throughput sequence shortlisting to support the development of aptamer-based analytical strategies
Aptamers are biomimetic receptors that are increasingly exploited for the development of optical and electrochemical aptasensors. They are selected...
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A novel fluorescent biosensor based on affinity-enhanced aptamer-peptide conjugate for sensitive detection of lead(II) in aquatic products
Lead contamination is a major concern in food safety and, as such, many lead detection methods have been developed, especially aptamer-based...
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Detection of ochratoxin A using a “turn-on” fluorescence assay based on guanine quenching of the aptamer
Ochratoxin A (OTA) is a common mycotoxin with high carcinogenicity; therefore, it is crucial to establish a simple, rapid, and sensitive method for...
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Aptamer-based impedimetric label-free detection of bisphenol A from water samples using a gold nanoparticle-modified electrochemical nanofilm platform
A label-free impedimetric aptasensor for bisphenol A (BPA) was developed based on a novel method. Initially, gold nanoparticle-based nanoplatforms...
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Tetrahedral DNA-linked aptamer-antibody-based sandwich-type electrochemical sensor with Ag@Au core-shell nanoparticles as a signal amplifier for highly sensitive detection of α-fetoprotein
The conventional electrochemical detection strategy for alpha-fetoprotein (AFP) is limited by the antigen-antibody (Ag-Ab) reactions and suffers from...
