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Genetic heterogeneity of cardiomyopathy and its correlation with patient care
BackgroundCardiomyopathy, which is a genetically and phenotypically heterogeneous pathological condition, is associated with increased morbidity and...
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Regulated cell death pathways in cardiomyopathy
Heart disease is a worldwide health menace. Both intractable primary and secondary cardiomyopathies contribute to malignant cardiac dysfunction and...
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The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes
Autophagy plays an important role in the development of diabetic cardiomyopathy. Cellular repressor of E1A-stimulated genes 1 (CREG1) is an important...
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Epigenetics in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate...
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Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of...
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Genetic therapies for cardiomyopathy: survey of attitudes of the patient community for the CureHeart project
Cardiomyopathies are a group of inherited heart muscle disorders. Expressivity is variable and while sometimes mild, complications can result in...
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Genome Editing and Diabetic Cardiomyopathy
Differential gene expression is associated with diabetic cardiomyopathy (DMCM) and culminates in adverse remodeling in the diabetic heart. Genome...
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Surveillance after childhood cancer: are survivors with an increased risk for cardiomyopathy regularly followed-up?
BackgroundWe aimed to study adherence to cardiac screening in long-term childhood cancer survivors (CCS) at high risk of cardiomyopathy.
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Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant
TNNI3 is a gene that causes hypertrophic cardiomyopathy (HCM). A 14-year-old girl who was diagnosed with nonobstructive HCM presented with...
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Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy
Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity, insulin resistance, and diabetes. It is characterized by...
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Intermittent Hypoxic Preconditioning Plays a Cardioprotective Role in Doxorubicin-Induced Cardiomyopathy
Intermittent hypoxic preconditioning (IHP) is a well-established cardioprotective intervention in models of ischemia/reperfusion injury....
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Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death
Cardiac myocyte death is an essential initiator of the pathogenesis and progression of various etiological cardiomyopathies, including diabetic...
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Epigenetics of Cardiomyopathy: Histone Modifications and DNA Methylation
AbstractCardiomyopathies are an actively investigated clinically and genetically heterogeneous group of myocardial pathologies. At present, it is...
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Novel insights into the role of mitochondria in diabetic cardiomyopathy: molecular mechanisms and potential treatments
Diabetic cardiomyopathy describes decreased myocardial function in diabetic patients in the absence of other heart diseases such as myocardial...
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The Scope of Mendelian Cardiomyopathy Genes
AbstractThe review analyses the scope of the genes of Mendelian cardiomyopathies (CM), specifically hypertrophic, dilated, arrhythmogenic, and...
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Renin Angiotensin System in the Pathophysiology of Diabetic Cardiomyopathy in Type 2 Diabetes
Type 2 diabetesDiabetes mellitus is associated with a high risk of heart failureHeart failure, in part because of its potential to induce impaired...
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Never in mitosis gene A-related kinase-6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72
AbstractNIMA (never in mitosis, gene A)-related kinase-6 (NEK6), a cell cycle regulatory gene, was found to regulate cardiac hypertrophy. However,...
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Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD+-SIRT3 pathway
Diabetic cardiomyopathy (DCM), one of the most serious long-term consequences of diabetes, is closely associated with oxidative stress, inflammation...
