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Reprogramming of Normal Cells into Human Pluripotent Stem Cells
Human pluripotent stem cells (hPSCs) have the potential to become the source of materials for cell-based therapy. The similarity of hPSCs with the...
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Maintenance of Human Pluripotent Stem Cells
During the last decades, the field of stem cell research has rapidly expanded with the potential to develop the technology of tissue regeneration as...
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Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cells
Congenital heart disease (CHD) is a leading cause of birth defect-related death. Despite significant advances, the mechanisms underlying the...
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Generation of Oligodendrocytes from Human Pluripotent and Embryonic Stem Cells
Oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes (OLs) can be generated using human induced pluripotent stem cells (hiPSCs) and...
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Cell therapy for Parkinson’s disease with induced pluripotent stem cells
Parkinson’s disease (PD) is the second most common neurodegenerative disease and a prime target of cell therapies. In fact, aborted fetal tissue has...
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Differentiation of Human Embryonic/Induced-Pluripotent Stem Cells to Retinal Ganglion Cells
The generation of retinal ganglion cells (RGCs) differentiated from human embryonic stem cell (hESC) or induced-pluripotent stem cells (iPSC) could...
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Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model
BackgroundRetinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials...
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Transcription Factor-Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells
The ability to differentiate pluripotent stem cells and to generate specific cell types is a long-standing goal of regenerative medicine. This can be...
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Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells
The blood-brain barrier (BBB) is a key physiological component of the brain, protecting the brain from peripheral processes and pathogens. The BBB is...
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Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells
BackgroundAcute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...
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Generation of Cerebral Cortical Neurons from Human Pluripotent Stem Cells in 3D Culture
Human forebrain cortical neurons are essential for fundamental functions like memory and consciousness. Generation of cortical neurons from human...
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Cancer Stem Cells
Cancer stem cells (CSCs) share traits with healthy stem or precursor cells, which include having the capacity to self-renew and differentiate into...
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Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route
The sympathetic nervous system (SNS) is a crucial branch of the autonomic nervous system (ANS) that is responsible for regulating visceral function...
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Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing
The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a...
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3D Bioprinting of Induced Pluripotent Stem Cells and Disease Modeling
Patient-derived induced pluripotent stem cells (iPSCs), carrying the genetic information of the disease and capable of differentiating into...
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Enabling Non-invasive Tracking of Vascular Endothelial Cells Derived from Induced Pluripotent Stem Cells Using Nuclear Imaging
PurposeThe absence of clinically applicable imaging techniques for continuous monitoring of transplanted cells poses a significant obstacle to the...
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Differentiation of Human Pluripotent Stem Cells (hPSCs) into Brown-Like Adipocytes
Increasing brown adipose tissue (BAT) mass and activation is a therapeutic strategy to prevent and treat obesity and associated complications. Obese...
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CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth
Cyclin-dependent kinase 5 (CDK5) is a protein kinase involved in neuronal homeostasis and development critical for neuronal survival. Besides, its...
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Multiplexed single-cell transcriptome analysis reveals molecular characteristics of monkey pluripotent stem cell lines
Efforts have been made to establish various human pluripotent stem cell lines. However, such methods have not yet been duplicated in non-human...